ABN117

Anti-PDE4D3 Antibody

from rabbit, purified by affinity chromatography

• 동의어(들): cAMP-specific 3′,5′-cyclic phosphodiesterase 4D, DPDE3, PDE43
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 정제법: affinity chromatography
• 종 반응성: rat, mouse, rhesus macaque
• 종 반응성(상동성에 의해 예측): human (immunogen homology), rhesus monkey (based on 100% sequence homology)
• 기술: western blot: suitable
• NCBI 수납 번호: NP_006194
• UniProt 수납 번호: Q08499
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... PDE4D(5144)

설명

일반 설명

Phosphodiesterase 4D3 (PDE4D3) is a member of the PDE cyclic nucleotides. PDE4D3 is known to be regulated by protein kinase C (PKC)-Raf-MEK-ERK and also by cAMP in vascular smooth muscle cells. PDE4D3 is a direct target of the MSH/cAMP/MITF pathway and may play a role in melanocyte differentiation. PDE4D3 is essential to have equilibrium in relaxing and contracting cues to airway smooth muscle. Down-regulation of PDE4D3 may be associated with analgesic and anti-inflammatory effects. PDE4D3 has also been linked to the risk of stroke, and in particular to polygenic stroke.

특이성

This antibody recognizes PDE4D3 at the N-terminus.

면역원

Epitope: N-terminus

KLH-conjugated linear peptide corresponding to the N-terminus of human PDE4D3.

애플리케이션

Research Category
Neuroscience

Research Sub Category
Developmental Neuroscience

This Anti-PDE4D3 Antibody is validated for use in WB for the detection of PDE4D3.

품질

Evaluated by Western Blot in mouse brain membrane tissue lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected PDE4D3 on 10 µg of mouse brain membrane tissue lysate.

표적 설명

~95 kDa observed. UniProt describes 12 isoforms produced by alternative splicing.

물리적 형태

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

분석 메모

Control
Mouse brain membrane tissue lysate

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable