ABN111

Anti-RGS11 (CT) Antibody

from rabbit

• 동의어(들): Regulator of G-protein signaling 11, RGS11
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 300
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 종 반응성: human, rat
• 기술: western blot: suitable
• NCBI 수납 번호: NP_003825
• UniProt 수납 번호: O94810
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... RGS11(8786)

설명

일반 설명

Regulator of G-protein signaling 11 (RGS11) is a multidomain GTPase containing one each of DEP, RGS, and G-protein gamma domains. Like other members of the R7 RGS family, RGS11 uses these domains to form multisubunit complexes, which process the light responses of retinal cells. RGS11 interacts with the RGS9 anchor protein (R9AP) and the 5 G-protein beta subunit (Gbeta5) to form a trimeric complex that regulates the activity of the metabotropic glutamate receptor 6 (mGluR6) in ON-bipolar cells. The RGS11 complex hydrolyzes GTP and inactivates the G-protein Galphao, which is activated by mGluR6 in dark environments. By this mechanism, the RGS11 complex accelerates the light response in ON-bipolar retinal cells.

특이성

This antibody recognizes the C-terminus of RGS11.

면역원

Epitope: C-terminus

KLH-conjugated linear peptide corresponding to the C-terminus of human RGS11.

애플리케이션

Detect RGS11 (C-terminus) using this Anti-RGS11 (C-terminus) Antibody validated for use in Western Blotting.

Research Category
Neuroscience

Research Sub Category
GPCR, cAMP/cGMP & Calcium Signaling

품질

Evaluated by Western Blot in human placenta tissue lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected RGS11 in 10 µg of human placenta tissue lysate.

표적 설명

~53 kDa observed

물리적 형태

Affinity purified

Format: Purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

분석 메모

Control
Human placenta tissue lysate

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids