ABE606

Anti-PERP Antibody

from rabbit, purified by affinity chromatography

• 동의어(들): p53 apoptosis effector related to PMP-22, PERP, Keratinocyte-associated protein 1, KCP-1, Krtcap1
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 정제법: affinity chromatography
• 종 반응성: human
• 기술: immunocytochemistry: suitable; western blot: suitable
• UniProt 수납 번호: A6NN79
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... PERP(64065)

설명

일반 설명

P53 apoptosis effector related to PMP-22 (PERP), also known as Keratinocyte-associated protein 1 (KCP-1, Krtcap1), is a member of the TMEM47 family and a component of the intercellular desmosome junctions. PERP has been shown to play an important role in the stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Recent evidence implies that PERP is a mediator of p53 induced apoptosis. P53 binds to the promoter of PERP and activates the PERP gene and consequently the translated PERP protein mediates the p53 induced apoptosis. PERP is expressed in apoptotic cells and in the stratified squamous skin epithelium of the skin and the tongue, but not in simple epithelia.

면역원

KLH-conjugated linear peptide corresponding to human PERP.

애플리케이션

Detect P53 apoptosis effector related to PMP-22 using this rabbit polyclonal antibody, Anti-PERP Antibody validated for use in western blotting & ICC.

Immunocytochemistry Analysis: 10 µg/mL from a representative lot detected PERP in A431 cells.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
RNA Metabolism & Binding Proteins

품질

Evaluated by Western Blotting/Peptide Inhibition Assay in A431 cell lysate.

Western Blotting/Peptide Inhibition Assay Analysis: 1 µg/mL of this antibody detected PERP in 15 µg of A431 cell lysate.

표적 설명

~21 kDa observed. Uncharacterized bands may appear in some lysate(s).

물리적 형태

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

분석 메모

Control
A431 cell lysate

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable