ABC424

Anti-Sec23A Antibody

from rabbit, purified by affinity chromatography

• 동의어(들): Protein transport protein Sec23A, SEC23-related protein A
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 정제법: affinity chromatography
• 종 반응성: rat, mouse
• 종 반응성(상동성에 의해 예측): human (based on 100% sequence homology)
• 기술: western blot: suitable
• NCBI 수납 번호: NP_033173
• UniProt 수납 번호: Q01405
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... SEC23A(10484) ; mouse ... Sec23A(20334) ; rat ... Sec23A(58817)

설명

일반 설명

The protein named Sec23a, also known as Sec23r, and encoded by the gene Sec23a/Sec23/Sec23r is a component of the COPII coat complex; this complex is the complex that governs ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. The transport of proteins in eukaryotic cells from the endoplasmic reticulum (ER) to the Golgi complex proceeds by deformation of specialized portions of the donor membrane to form carrier vesicles. A group of cytosolic proteins collectively known as COPII carry out a programmed set of sequential interactions, leading to cargo sorting and vesicle budding. The Sec23A protein is critical to proper protein transport in and out of cells, and it is localized to the smooth endoplasmic reticulum membrane where it is a peripheral membrane protein and interacts with the Golgi apparatus membranes as well. Sec23A is expressed at high levels in brain and fibroblasts as well as liver and other metabolically active tissues. Sec23A interacts with SEC23IP, HTR4, SEC16A and SLC6A proteins. Sec23A also appears to play a role directly in development as recent research linked Sec23A promoters to important developmental transcription factors such as TFII-1 and showed that important craniofacial and dental developmental genes could contribute to the WBS-specific facial dysmorphism in Williams-Beuren syndrome.

면역원

Linear peptide corresponding to mouse Sec23A.

애플리케이션

Detect Sec23a using this rabbit polyclonal antibody, Anti-Sec23A Antibody validated for use in western blotting.

Western Blotting Analysis: 1 µg/mL from a representative lot detected Sec23A in 10 µg of mouse heart, thymus, pancreas, testis, and adrenal gland tissues.

Western Blotting Analysis: A representative lot from an independent laboratory detected Sec23A in various mouse tissues expressing wildtype Sec23A (Tao, J., et al. (2012). Proc Natl Acad Sci USA. 109(29):E2001-2009.).

품질

Evaluated by mouse brain tissue lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected Sec23A in 10 µg of mouse brain tissue lysate.

표적 설명

~86 kDa observed. Uncharacterized band(s) may be observed in some cell lysates.

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable