생물학적 소스
rabbit
항체 형태
serum
항체 생산 유형
primary antibodies
클론
polyclonal
종 반응성(상동성에 의해 예측)
all
제조업체/상표
Chemicon®
기술
ELISA: suitable
immunohistochemistry: suitable
배송 상태
dry ice
유전자 정보
human ... NOS1(4842)
일반 설명
The cellular production of highly reactive nitrogen species derived from nitric oxide, such as peroxynitrite, nitrogen dioxide and nitryl chloride, leads to the nitration of tyrosine resides in tissue proteins. The extent of protein nitrotyrosine formation provides an index of the production of reactive nitrogen species and potential cell damage over a period of time. Nitrotyrosine can be measured by amino-acid analysis of protein hydrolysates and detected, estimated semi-quantitatively and located in cells and tissues by immunocytochemical techniques using antibodies directed against the nitrotyrosine hapten.
특이성
NO2-Tyrosine
The cross-reactivities were determined using an ELISA test by competition experiments with the following compounds:
Compound Cross-reactivity ratio
NO2-Tyrosine-G-BSA 1
NO-Tyr-G-BSA 1/233
Tyr-G-BSA 1/>100,000
NO2-5HT-G-BSA 1/>100,000
NO-5HT-G-BSA 1/>100,000
NO-Cys-G-BSA 1/>100,000
NO-W-G-BSA 1/>100,000
NO-His-G-BSA 1/>100,000
Abbreviations:
(G) Glutaraldehyde
(BSA) Bovine Serum Albumin
The cross-reactivities were determined using an ELISA test by competition experiments with the following compounds:
Compound Cross-reactivity ratio
NO2-Tyrosine-G-BSA 1
NO-Tyr-G-BSA 1/233
Tyr-G-BSA 1/>100,000
NO2-5HT-G-BSA 1/>100,000
NO-5HT-G-BSA 1/>100,000
NO-Cys-G-BSA 1/>100,000
NO-W-G-BSA 1/>100,000
NO-His-G-BSA 1/>100,000
Abbreviations:
(G) Glutaraldehyde
(BSA) Bovine Serum Albumin
면역원
NO2-Tyrosine-Glutaraldehyde-BSA
애플리케이션
Anti-Nitrotyrosine Antibody is an antibody against Nitrotyrosine for use in ELISA, IH.
Immunohistochemistry: 1:1,000-1:2,500
Optimal working dilutions must be determined by the end user.
Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Oxidative Stress
Oxidative Stress
물리적 형태
Rabbit antiserum. Liquid with 0.05% sodium azide.
저장 및 안정성
Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
법적 정보
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Usua Laresgoiti et al.
Development (Cambridge, England), 143(20), 3686-3699 (2016-11-02)
Insufficient alveolar gas exchange capacity is a major contributor to lung disease. During lung development, a population of distal epithelial progenitors first produce bronchiolar-fated and subsequently alveolar-fated progeny. The mechanisms controlling this bronchiolar-to-alveolar developmental transition remain largely unknown. We developed
S Y Yao et al.
Journal of neuroimmunology, 229(1-2), 146-156 (2010-08-21)
There are currently four known isoforms of nitric oxide synthase (NOS). Of these, neuronal NOS (nNOS) is known to be present exclusively in neurons, endothelial NOS (eNOS) in vascular endothelium, while the inducible form of NOS (iNOS) is known to
Maria A Pabón et al.
JCI insight, 3(18) (2018-09-21)
Chronic obstructive pulmonary disease (COPD), associated with cigarette smoke-induced (CS-induced) emphysema, contributes significantly to the global health care burden of disease. Although chronic kidney disease (CKD) may occur in patients with COPD, the relationship between COPD and CKD remains unclear.
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