AB2285

Anti-Glutamate Receptor Delta 1/2 Antibody

from rabbit, purified by affinity chromatography

• 동의어(들): GluR delta-1, glutamate receptor, ionotropic, delta 1
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 정제법: affinity chromatography
• 종 반응성: rat, mouse, primate, human
• 기술: western blot: suitable
• NCBI 수납 번호: NM_017551.2
• UniProt 수납 번호: Q9ULK0
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... GRID1(2894)

설명

일반 설명

The majority of rapid excitatory transmission in the nervous system is mediated by glutamate-activated ion channels. Ionotropic glutamate receptors have been subdivided pharmacologically into AMPA (cx-amino-3-hydroxy-5methyl-Cisoxazole propionic acid), KA (kainate), and NMDA subtypes (Monaghan et al., 1989). These receptors have been implicated in a number of physiological and pathological processes. During development glutamate receptors are involved in neuronal differentiation, migration, and activity-dependent synapse formation (Balazs et al., 1989; Brewer, 1989; Komoru and Rakic, 1993). In mature neurons, long-term potentiation and long-term depression require ionotropic glutamate receptors. Glutamate-gated ion channels also play a central role in mediating the excitotoxic effects of glutamate (Olney, 1990). Pathophysiological processes thought to involve glutamate excitotoxicity and neurodegeneration include epilepsy stroke, Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and amyotrophic lateral sclerosis.

특이성

Cat. # AB2285 reacts with the C-Terminus of Glutamate Receptor Delta 1/2.

Reacts weakly with mouse. May react with Primate based on sequence homology. Reactivity with other species has not been tested.

면역원

Epitope: C-Terminus, Cytoplasmic

Synthetic linear peptide to the C-Terminus, conjugated to BSA.

애플리케이션

Anti-Glutamate Receptor Delta 1/2 Antibody detects level of Glutamate Receptor Delta 1/2 & has been published & validated for use in WB.

Research Category
Neuroscience

Research Sub Category
Neurotransmitters & Receptors

Western Blotting:
Human Cerebellum Lysate.

품질

Western Blotting: 1:5,000 dilution from a previous lot detected Glutamate Receptor Delta 1/2 on 10 µg of rat or human cerebellum lysate.

표적 설명

~114 kDa

물리적 형태

Antigen Affinity Purified

Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3.

저장 및 안정성

Stable for 1 year at 2-8ºC from date of receipt.

분석 메모

Control
Rat cerebellum tissue lysate and human cerebellum tissue lysate.

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable