681677
Wnt Pathway Inhibitor XII
The Wnt Pathway Inhibitor XII controls the biological activity of Wnt Pathway. This small molecule/inhibitor is primarily used for Cancer applications.
동의어(들):
Wnt Pathway Inhibitor XII, (E)-4-(2,6-Difluorostyryl)-N,N-dimethylaniline, FIDAS3, MAT2A Inhibitor I, Methionine S-Adenosyltransferase 2A Inhibitor I
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모든 사진(1)
About This Item
Quality Level
분석
≥95% (HPLC)
양식
solid
제조업체/상표
Calbiochem®
저장 조건
OK to freeze
protect from light
색상
off-white to pale yellow
solubility
DMSO: 50 mg/mL
배송 상태
ambient
저장 온도
2-8°C
일반 설명
A cell-permeable fluorinated N,N-dialkylaminostilbene (FIDAS) compound that inhibits MAT2A-catalyzed SAM (S-adenosylmethionine) synthesis (IC50 =4.9 µM; [L-Met] = [ATP] = 1 mM, [MAT2A] = 10 µg/mL; 20 min preincubation prior to 30 min reaction) by targeting SAM-binding pocket at the MAT2A dimer interface. Shown to downregulate intracellular SAM level (by 64%; 36 h;10 µM) and Wnt signaling in LS174 CRC (colorectal cancer) cultures and is at least 10-fold more potent than its analogs Pterostilbene (Cat. No. 523310) and Resveratrol (Cat. No. 554325) in inhibiting LS174 proliferation both in vitro (by 70%, 85%, and 90% in 4 d, respectively, with 0.1, 0.3, and 1 µM inhibitor) and in mice in vivo (by 75% on d26; 20 mg/kg/day; i.p.).
A cell-permeable fluorinated N,N-dialkylaminostilbene (FIDAS) compound that inhibits MAT2A-catalyzed SAM (S-adenosylmethionine) synthesis by targeting SAM-binding pocket at the MAT2A dimer interface. Shown to downregulate intracellular SAM level (by 64%; 36 h;10 µM) and Wnt signaling in LS174 colorectal cancer cultures and is at least 10-fold more potent than Pterostilbene (Cat. No. 523310) and Resveratrol (Cat. No. 554325) in inhibiting LS174 proliferation both in vitro (by 90% in 4 d; 1 µM) and in mice in vivo (by 75% on d26; 20 mg/kg/day; i.p.).
포장
Packaged under inert gas
경고
Toxicity: Regulatory Review (Z)
기타 정보
Zhang, W., et al. 2013. ACS Chem.Biol.18, In press.
Zhang, W., et al. 2011. J. Med. Chem.54, 7579.
Zhang, W., et al. 2011. J. Med. Chem.54, 7579.
법적 정보
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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