676494

VEGF Inhibitor, Je-11 - Calbiochem

• 동의어(들): VEGF Inhibitor, Je-11 - Calbiochem, (RTELNVGIDFNWEYPAS)₂K-NH₂, VEGFR Tyrosine Kinase Inhibitor XI, VEGFR2 Kinase Inhibitor XII
• 실험식(Hill 표기법): C₁₈₈H₂₇₃N₄₉O₅₇
• Molecular Weight: 4131.47
• UNSPSC 코드: 12352200

속성

• 분석: ≥90% (HPLC)
• Quality Level: 100
• 형태: lyophilized solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic)
• 색상: white
• solubility: DMSO: 5 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C

설명

일반 설명

This product has been discontinued.

A dimerized peptide derived from the third Ig-like domain of the human vascular endothelial growth factor receptor-2 (VEGFR-2 or KDR/Flk-1) comprising residues 247 - 261. Acts as an inhibitor of VEGF-stimulated autophosphorylation of VEGFR-2 and inhibits the proliferation and migration of cultured microvascular endothelial cells. Binds to VEGF and blocks its interaction with VEGFR-2 (IC₅₀ = 500 nM on extracellular VEGFR-2 fragments; IC₅₀ = 30 µM on HUVEC).

A dimerized peptide derived from the third Ig-like domain of the human vascular endothelial growth factor receptor-2 (VEGFR-2 or KDR/FLK-1) comprising residues 247-261. Acts as an inhibitor of VEGF-stimulated autophosphorylation of VEGFR-2 (IC₅₀ = 500 nM on extracellular VEGFR-2 fragments; IC₅₀ = 30 µM on HUVEC).

생화학적/생리학적 작용

Cell permeable: no

Primary Target
Binds to VEGF and blocks its interaction with VEGFR-2

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 500 nM on extracellular VEGFR-2 fragments; 30 µM on HUVEC

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

서열

(H-Arg-Thr-Glu-Leu-Asn-Val-Gly-Ile-Asp-Phe-Asn-Trp-Glu-Tyr-Pro-Ala-Ser)₂-Lys-NH₂

물리적 형태

Supplied as a trifluoroacetate salt.

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Piossek, C., et al. 1999. J. Biol. Chem.274, 5612.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 10-13 - German Storage Class 10 to 13