658460

AG 879 - CAS 148741-30-4 - Calbiochem

A cell-permeable, reversible, and substrate competitive inhibitor of nerve growth factor (NGF)-dependent p140^c-trk tyrosine phosphorylation (EC₅₀ = 10 µM) as well as NGF-induced phospholipase C-γ1 phosphorylation.

• 동의어(들): AG 879 - CAS 148741-30-4 - Calbiochem, α-Cyano-(3,5-di- t-butyl-4-hydroxy)thiocinnamide
• 실험식(Hill 표기법): C₁₈H₂₄N₂OS
• CAS Number: 148741-30-4
• Molecular Weight: 316.46
• MDL number: MFCD00236450
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: orange-yellow
• solubility: DMSO: 100 mg/mL; acetic acid: soluble; methanol: soluble
• 배송 상태: ambient
• 저장 온도: −20°C
• InChI: 1S/C18H24N2OS/c1-17(2,3)13-8-11(7-12(10-19)16(20)22)9-14(15(13)21)18(4,5)6/h7-9,22H,20H2,1-6H3/b16-12+
• InChI key: LCUMYVYIHXYBIA-FOWTUZBSSA-N

설명

일반 설명

A cell-permeable, reversible, and substrate competitive inhibitor of nerve growth factor (NGF)-dependent p140^c-trk tyrosine phosphorylation (EC₅₀ = 10 µM) as well as NGF-induced phospholipase C-γ1 phosphorylation. Also blocks NGF-induced neurite outgrowth in PC12 cells. Does not affect the tyrosine phosphorylation of epidermal growth factor receptor or platelet-derived growth factor receptor. Inhibits insulin secretion in a dose-dependent manner.

A cell-permeable, reversible, and substrate competitive inhibitor of nerve growth factor (NGF)-dependent pp140^c-trk tyrosine phosphorylation (EC₅₀ = 10 µM), as well as NGF-induced phospholipase C-γ1 phosphorylation. Also shown to inhibit HER2 (IC₅₀ = 1 µM). Does not affect the tyrosine phosphorylation of epidermal growth factor receptor or platelet-derived growth factor receptor. Also inhibits insulin secretion in a dose-dependent manner.

생화학적/생리학적 작용

Cell permeable: yes

EC50 = 10 µM inhibiting nerve growth factor (NGF)-dependent p140c-trk tyrosine phosphorylation

Primary Target
(NGF)-dependent p140c-trk tyrosine phosphorylation

Product does not compete with ATP.

Reversible: yes

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.







From Catalog:

Solubility- removed acetic acid, MeOH

기타 정보

Konrad, R.J., et al. 1996. J. Biol. Chem. 271, 24179.
Levitzki, A. and Gazit, A. 1995. Science. 267, 1782.
Ohmichi, M., et al. 1993. Biochemistry32, 4650.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 10-13 - German Storage Class 10 to 13