580551

Tautomycin, Streptomyces spiroverticillatus

Tautomycin, CAS 109946-35-2, is a potent inhibitor of protein phosphatase 1, 2A, and smooth muscle endogenous phosphatase (IC₅₀ = 1 nM, 10 nM, and 6 nM, respectively). Mixture of two isomers.

• 동의어(들): Tautomycin, Streptomyces spiroverticillatus
• 실험식(Hill 표기법): C₄₁H₆₆O₁₃
• CAS Number: 109946-35-2
• Molecular Weight: 766.95
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥97% (HPLC)
• 형태: lyophilized (thin film)
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated; protect from light
• solubility: chloroform: soluble; ethanol: soluble; methanol: soluble
• 배송 상태: ambient
• 저장 온도: −20°C
• InChI: 1S/C41H66O13/c1-21(2)36(51-34(47)20-31(45)35-27(8)39(48)52-40(35)49)38(50-10)32(46)19-30(44)26(7)29(43)13-11-24(5)37-25(6)16-18-41(54-37)17-15-23(4)33(53-41)14-12-22(3)28(9)42/h21-26,29,31-33,36-38,43,45-46H,11-20H2,1-10H3/t22-,23+,24+,25-,26-,29-,31+,32+,33-,36+,37-,38+,41+/m0/s1
• InChI key: RFCWHQNNCOJYTR-IRCAEPKSSA-N

설명

일반 설명

Mixture of two isomers. Potent inhibitor of protein phosphatases and useful for studies involving protein phosphorylation. Inhibits protein phosphatase 1 (IC₅₀ = 1 nM), protein phosphatase 2A (IC₅₀ = 10 nM), and smooth muscle endogenous phosphatase (IC₅₀ = 6 nM). Higher concentrations are needed to inhibit protein phosphatase 2B. Does not inhibit protein phosphatase 2C or phorbol dibutyrate binding. Does not activate protein kinase C or inhibit myosin light chain kinase.

Mixture of two isomers. Potent inhibitor of protein phosphatases. Inhibits protein phosphatase 1 (IC₅₀ = 1 nM), protein phosphatase 2A (IC₅₀ = 10 nM), and smooth muscle endogenous phosphatase (IC₅₀ = 6 nM). Higher concentrations are needed to inhibit protein phosphatase 2B. Does not inhibit protein phosphatase 2C.

생화학적/생리학적 작용

Cell permeable: no

Primary Target
PP1

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 1 nM, 10 nM, 6 nM, against protein phosphatase 1, protein phosphatase 2A, and smooth muscle endogenous phosphatase, respectively

경고

Toxicity: Highly Toxic (H)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.







From Catalog:

Desc. Field- removed ". . .and useful for studies involving protein phosphorylation"

- removed ". . .or phorbol dibutyrate binding. Does not activate protein kinase C or inhibit myosin light chain kinase"

기타 정보

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

McCluskey, A., et al. 2002. J. Med. Chem.45, 1151.
Mitsuhashi, S., et al. 2001. Biochem. Biophys. Res. Commun.287, 328.
Kikuchi, K., et al. 1999. Int. J. Mol. Med.4, 395.
Sheppeck, J.E., et al. 1997. J. Org. Chem.62, 387.
Sugiyama, Y., et al. 1996. Bioorg. Med. Chem. Lett.6, 3.
Gong, M.C., et al. 1992. J. Biol. Chem.267, 14662.
Suganuma, M., et al. 1992. Toxicon30, 873.
MacKintosh, C. and Klumpp, S. 1990. FEBS Lett.277, 137.
Magae, J., et al. 1989. J. Antibiot.42, 1290.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H300
• 예방조치 성명서: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 2 Oral
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable