567693

SOST, Mouse, Recombinant

• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 분석: ≥90% (SDS-PAGE)
• Quality Level: 100
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 불순물: <1.0 EU/μg protein Endotoxin
• 배송 상태: ambient
• 저장 온도: −20°C

설명

일반 설명

Recombinant, mouse sclerostin (SOST) consisting of amino acids 24-211, expressed in NS0-derived murine myeloma cells with an N-terminal His•Tag. SOST is expressed by osteoclasts in developing bones of mouse embryos and acts as a negative regulator of bone formation through repression of BMP-induced osteogenesis.

생화학적/생리학적 작용

Inhibition Assay: Inhibits hBMP-6-induced alkaline phosphatase by 50-80% in MC3T3-E1 mouse osteoblastic cells when used at a concentration of 30 µg/ml.

경고

Toxicity: Standard Handling (A)

물리적 형태

Lyophilized from 0.2 µm filter-sterilized PBS, BSA.

재구성

Following reconstitution refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.

Reconstitute to 200 µg/ml in sterile PBS containing at least 0.1% human or bovine serum albumin.

기타 정보

Kusu, N. et al. 2003. J. Biol. Chem.278, 24113.
Balemans, W. et al. 2001. Hum. Mol. Genet.10 537.
Brunkow, M.E. et al. 2001. Am. J. Hum. Genet.68, 577.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3