538916

16,16-Dimethyl Prostaglandin E2 - CAS 39746-25-3 - Calbiochem

A cell-permeable and orally available synthetic PGE2.

• 동의어(들): 16,16-Dimethyl Prostaglandin E2 - CAS 39746-25-3 - Calbiochem
• 실험식(Hill 표기법): C₂₂H₃₆O₅
• CAS Number: 39746-25-3
• Molecular Weight: 380.52
• MDL number: MFCD00151141
• UNSPSC 코드: 12352200

속성

• 분석: ≥95% (HPLC)
• 양식: liquid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• solubility: DMSO: 100 mg/mL; ethanol: 100 mg/mL; PBS, pH 7.2: 5 mg/mL
• 배송 상태: wet ice
• 저장 온도: −70°C
• InChI: 1S/C22H36O5/c1-4-5-14-22(2,3)20(25)13-12-17-16(18(23)15-19(17)24)10-8-6-7-9-11-21(26)27/h6,8,12-13,16-17,19-20,24-25H,4-5,7,9-11,14-15H2,1-3H3,(H,26,27)/b8-6+,13-12+/t16-,17?,19-,20+/m0/s1
• InChI key: QAOBBBBDJSWHMU-BKSAQPBESA-N

설명

일반 설명

A cell-permeable and orally available synthetic PGE2.

A cell-permeable and orally available synthetic PGE₂ (Cat. No. 538904) 16,16-dimethyl derivative that exhibits similar biological activity as PGE₂ as an EP receptor agonist both in in vitro and in in vivo, while being more resistant to PGDH metabolism. Shown to amplify wnt activity through cAMP/PKA-mediated regulation of cellular β-catenin protein stability during vertebrate development and organ regeneration.

A cell-permeable and orally available synthetic PGE₂ (Cat. No. 538904) 16,16-dimethyl derivative that exhibits similar biological activity as PGE₂ as an EP receptor agonist both in in vitro and in in vivo, while being more resistant to PGDH metabolism. Shown to amplify wnt activity through cAMP/PKA-mediated regulation of cellular β-catenin protein stability during vertebrate development and organ regeneration.

경고

Toxicity: Flammable (J)

물리적 형태

Supplied as a solution in methylacetate (1 mg/100 µL)

제조 메모

Gently blow away methylacetate under a stream of N2 and solubilize in either DMSO or EtOH purged with an inert gas.

재구성

Following reconstitution in DMSO or EtOH store at ≤-70°C for up to 6 months; Store aqueous solutions on ice and use within 12 hrs.

기타 정보

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Goessling, W., et al. 2009. Cell136, 1136.
Fitzgerald, J., et al. 2000. Endocrinology141, 291.
Coleman, R.A., et al. 1994. Pharmacol. Rev.46, 205.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS02,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H225,H319,H336
• 예방조치 성명서: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
• 표적 기관: Central nervous system
• 보충제 위험성: EUH066
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point (°F): 3.2 °F - closed cup
• Flash Point (°C): -16 °C - closed cup