528105

Picrotoxin, Anamirta cocculin

A potent antagonist of GABA receptors (IC₅₀ = 240 nM) at synapses in the central nervous system.

• 동의어(들): Picrotoxin, Anamirta cocculin
• 실험식(Hill 표기법): C₁₅H₁₈O₇ · C₁₅H₁₆O₆
• CAS Number: 124-87-8
• Molecular Weight: 602.58
• MDL number: MFCD00074824
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (mixture of Picrotoxin and picrotin, HPLC)
• 형태: crystals; powder
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 색상: white to light yellow
• solubility: aqueous base: 3 mg/mL; ethanol: 50 mg/mL
• 배송 상태: ambient
• 저장 온도: 10-30°C
• InChI: 1S/C15H18O7.C15H16O6/c1-12(2,18)6-7-10(16)20-8(6)9-13(3)14(7,19)4-5-15(13,22-5)11(17)21-9;1-5(2)7-8-11(16)19-9(7)10-13(3)14(8,18)4-6-15(13,21-6)12(17)20-10/h5-9,18-19H,4H2,1-3H3;6-10,18H,1,4H2,2-3H3/t5-,6+,7?,8?,9-,13-,14-,15+;6?,7-,8?,9?,10+,13+,14+,15-/m10/s1
• InChI key: VJKUPQSHOVKBCO-ZTYBEOBUSA-N

설명

일반 설명

A potent antagonist of GABA receptors (IC₅₀ = 240 nM) at synapses in the central nervous system. Inhibits ³⁵S-TBPS binding to the Cl^– channel (IC₅₀ = 1.7 µM). Picrotoxin is a mixture of one mole of picrotoxinin and one mole of picrotin.

A potent antagonist of GABA receptors (IC₅₀ = 240 nM) at synapses in the central nervous system. Inhibits ³⁵S-TBPS binding to the Cl^- channel (IC₅₀ = 1.7 µM). Picrotoxin is a mixture of one mole of picrotoxinin and one mole of picrotin.

생화학적/생리학적 작용

Cell permeable: no

Primary Target
GABA receptors

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 240 nM against GABA receptors

경고

Toxicity: Highly Toxic (H)

기타 정보

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Qian, H., and Dowling, J.E. 1994. J. Neurosci. 14, 4299.
Yoon, K.W., et al. 1993. J. Physiol.464, 423.
Akaike, N., et al. 1985. Experientia41, 70.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H300
• 예방조치 성명서: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 2 Oral
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable