5.05823

Galectin-1 Antagonist, DB21

• 동의어(들): Galectin-1 Antagonist, DB21, SVQNvaKL-[DBF]-IIVKLNA
• 실험식(Hill 표기법): C₈₃H₁₃₂N₁₈O₁₇
• Molecular Weight: 1654.05
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• Quality Level: 100
• 형태: powder
• 효능: 3 μM IC₅₀
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: white
• solubility: DMSO: 10 mg/mL
• 저장 온도: −20°C

설명

일반 설명

A dibenzofuran conjugated peptidomimetic (13-mer) that acts as an allosteric inhibitor of galectin-1 binding to cell surface glycans (IC₅₀ = 3 µM). Shown to reduce the proliferation of endothelial cells and reduce vessel density in murine tumor models.

A dibenzofuran conjugated peptidomimetic (13-mer) that acts as an allosteric inhibitor of galectin-1 binding to cell surface glycans (IC₅₀ = 3 µM). Shown to reduce the proliferation of endothelial cells and reduce vessel density in murine tumor models.

생화학적/생리학적 작용

Primary Target
Galectin-1

Reversible: yes

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

서열

SVQMKNva-[DBF]-IIVKLNA

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Dings, R.P., et al, 2013, J. Pharm. Exp. Ther.344, 589.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable