5.04744

Aphidicolin

≥98% (TLC), liquid, DNA polymerase α and δ inhibitor, Calbiochem

• 동의어(들): InSolution Aphidicolin
• 실험식(Hill 표기법): C₂₀H₃₄O₄
• CAS Number: 38966-21-1
• Molecular Weight: 338.48
• MDL number: MFCD00083214
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• product name: Aphidicolin, InSolution, ≥98%, 30 mM in DMSO, A cell-permeable tetracyclic diterpene antibiotic
• Quality Level: 100
• 분석: ≥98% (TLC)
• 형태: liquid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• 저장 온도: −70°C
• InChI: 1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1
• InChI key: NOFOAYPPHIUXJR-APNQCZIXSA-N

설명

일반 설명

A cell-permeable tetracyclic diterpene antibiotic. Cell synchronization agent. Blocks the cell cycle at the early S-phase. Specific, non-competitive and reversible inhibitor of DNA polymerase α and δ in eukaryotic cells and in some viruses of animal origin. Potentiates apoptosis induced by arabinosyl nucleosides in leukemia cell lines. Also induces apoptosis in HeLaS3 cells, but inhibits vincristine (>Cat. No. 677181)-induced apoptosis in the p53-negative human prostate cancer cell line PC-3.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
DNA polymerase α and δ

Reversible: yes

포장

Packaged under inert gas

경고

Toxicity: Irritant (B)

물리적 형태

A 30 mM (1 mg/98 µL) sterile-filtered solution of Aphidicolin (Cat. No. 178273) in DMSO.

재구성

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. Use only fresh DMSO for further dilutions.

기타 정보

Borner, M.M., et al. 1995. Cancer Res.55, 2122.
Poluha, W., et al. 1995. Oncogene10, 185.
Urbani, L., et al. 1995. Exp. Cell Res.219, 159.Schimke, R.T., et al. 1994. Philos. Trans. R. Soc. London. B. Biol. Sci.345, 311.Kuwakado, K., et al. 1993. Biochem. Pharmacol.46, 1909.Hubermann, J.A. 1981. Cell23, 647.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): 188.6 °F - (refers to pure substance)
• Flash Point (°C): 87 °C - (refers to pure substance)