5.04345

BX471

• 동의어(들): BX471, N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-urea, ZK-811752
• 실험식(Hill 표기법): C₂₁H₂₄ClFN₄O₃
• CAS Number: 217645-70-0
• Molecular Weight: 434.89
• UNSPSC 코드: 12352200

속성

• 분석: ≥98% (HPLC)
• Quality Level: 100
• 형태: powder
• 효능: 1-5 nM K_i
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: white to beige
• solubility: DMSO: ≥25 mg/mL
• 저장 온도: 2-8°C
• InChI: 1S/C21H24ClFN4O3/c1-14-11-26(12-15-2-5-17(23)6-3-15)8-9-27(14)20(28)13-30-19-7-4-16(22)10-18(19)25-21(24)29/h2-7,10,14H,8-9,11-13H2,1H3,(H3,24,25,29)/t14-/m1/s1
• InChI key: XQYASZNUFDVMFH-CQSZACIVSA-N

설명

일반 설명

An orally active, selective antagonist for chemokine receptor 1 (CCR-1) (K_i = 1-5 nM). Has been used in studies related to intracellular calcium mobilization and migration of leukocytes mediated through CCR-1.

생화학적/생리학적 작용

Primary Target
CCR1

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Shahlaei, M., et al. 2011. J. Chemical Information and Modeling.51, 2717.

Reuss, R., et al. 2010. Mult Scler.16, 366.

Gladue, R., et al. 2010. Curr Top Med Chem10, 1268.

Vandemeulebroecke; M., et al. 2009. British J. of Clinical Pharmacol.68, 435.

Richard Horuk, R. 2005. Mini-Reviews in Medicinal Chemistry.5, 791.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°C): Not applicable