5.04275

CB1 antagonist AM251

• 동의어(들): CB1 antagonist AM251, N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide, AM 251
• 실험식(Hill 표기법): C₂₂H₂₁Cl₂IN₄O
• CAS Number: 183232-66-8
• Molecular Weight: 555.24
• MDL number: MFCD01861181
• UNSPSC 코드: 12352200

속성

• 분석: ≥98% (HPLC)
• Quality Level: 100
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: white
• solubility: DMSO: 10 mg/mL
• 저장 온도: 10-30°C
• InChI: 1S/C22H21Cl2IN4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-7-16(23)13-18(19)24)21(14)15-5-8-17(25)9-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30)
• InChI key: BUZAJRPLUGXRAB-UHFFFAOYSA-N

설명

일반 설명

A potent and highly selective antagonist for cannabinoid subtyre 1 (CB₁) receptor. Affinity for CB1 (IC₅₀ = 8 nM, K_i = 7.49 nM) is more than 306-fold higher than that for CB₂ receptors. Has been used in a study to determine its interaction with hippocampal neurons to enhance spatial memory in mice.

생화학적/생리학적 작용

Primary Target
CB₁ Receptor

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Gatley, S., et al. 1996. Eur. J. Pharmacol.307, 331.
Gatley, S., et al. 1997. Life Sci.61, 191.
Lan, R., et al. 1999. J. Med. Chem.42, 769.
Pertwee, R., 2005. Life Sci.76, 1307.

Ryberg, E., et al. 2007. Br. J. Pharmacol.152, 1092.
Assini, F., et al. 2012. Behav. Pharmacol.23, 292.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°C): Not applicable