454861

MNK1 Inhibitor

The MNK1 Inhibitor, also referenced under CAS 522629-08-9, controls the biological activity of MNK1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 동의어(들): MNK1 Inhibitor, 4-Amino-5-(4-fluoroanilino)-pyrazolo[3,4-d]pyrimidine, CGP 57380, MNK Inhibitor I, Mitogen-Activated Protein Kinase-Interacting Kinase Inhibitor I
• 실험식(Hill 표기법): C₁₁H₉FN₆
• CAS Number: 522629-08-9
• Molecular Weight: 244.23
• MDL number: MFCD03861062
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: off-white
• solubility: DMSO: 15 mg/mL; ethanol: 5 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• InChI: 1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)
• InChI key: UQPMANVRZYYQMD-UHFFFAOYSA-N

설명

일반 설명

A cell-permeable, reversible, and ATP-competitive pyrazolo-pyrimidine compound that acts as a selective inhibitor of mitogen-activated protein kinase-interacting kinase 1 (MNK1; IC₅₀ = 2.2 µM) with no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases. Effectively inhibits eIF4E phosphorylation (IC₅₀ = 3 µM) by MNK1 in 293 human embryonic kidney cells and serves as a useful tool in studying MNK1-mediated cellular signaling.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
Mitogen-activated protein kinase-interacting kinase 1 (MNK1)

Product competes with ATP.

Reversible: yes

Target IC₅₀: 2.2 µM against mitogen-activated protein kinase-interacting kinase 1 (MNK1); 3 µM against eIF4E phosphorylation by MNK1 in 293 human embryonic kidney cells

포장

Packaged under inert gas

경고

Toxicity: Toxic (F)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

기타 정보

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Topisirovic, I., et al. 2004. Cancer Res.64, 8639.
Worch, J., et al. 2004. Oncogene23, 9162.
Walsh, D., and Mohr, I. 2004. Genes Dev.18, 660.
Morley, S.J., and Naegele, S. 2002. J. Biol. Chem.277, 32855.
Knauf, U., et al. 2001. Mol. Cell. Biol.21, 5500.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3