444294-M

MMP-2 Inhibitor IV

The MMP-2 Inhibitor IV controls the biological activity of MMP-2. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• 동의어(들): MMP-2 Inhibitor IV, (4′-chlorobiphenyl-4-ylsulfonamido)methylenediphosphonic acid, Bone Resorption Inhibitor, Bone Resorption Inhibitor, (4′-chlorobiphenyl-4-ylsulfonamido)methylenediphosphonic acid
• 실험식(Hill 표기법): C₁₃H₁₄ClNO₈P₂S
• Molecular Weight: 441.72
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥99% (HPLC)
• 형태: powder
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: off-white
• solubility: DMSO: 100 mg/mL, clear, colorless
• 저장 온도: 2-8°C

설명

일반 설명

A cell-permeable, bisphosphonate derivative that displays nanomolar activity against MMP-2 (IC₅₀ = 37 nM), with good selectivity over MMP-8 (320 nM), MMP-9 (>1 M), and MMP-14 (>1 M). It is shown to inhibit osteoclast activity in a macrophage cell line, J774 (IC₅₀ = 1.7 M), which is more potent compared with other bisphosphonates such as Alendronate (Cat. No. 126855), (IC₅₀ = 30 M), and Zolendronate (7.8 M), without observable cytotoxicity in HepG2 cells. At 25 M, it abolishes the formation of actin rings, which are functional structures that are typical of resorbing osteoclasts, at activity levels comparable with those of zolendronic acid, inhibits bone resportion in vitro, and demonstrates cytotoxic properties in murine osteoclasts.

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Rubino, M.T., et al. 2011. Chem. Med. Chem.6, 1258.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable