444251-M

MMP-2/MMP-9 Inhibitor III

The MMP-2/MMP-9 Inhibitor III controls the biological activity of MMP-2/MMP-9. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• 동의어(들): MMP-2/MMP-9 Inhibitor III
• 실험식(Hill 표기법): C₅₂H₇₁N₁₃O₁₄S₂
• Molecular Weight: 1166.33
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥97% (HPLC)
• 형태: lyophilized solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic)
• 색상: white
• solubility: water: 5 mg/mL
• 저장 온도: −20°C

설명

일반 설명

A cyclic peptide that acts as a potent inhibitor of MMP-2 (gelatinase A; IC₅₀ = 10 µM) and MMP-9 (gelatinase B; IC₅₀ = 10 µM). Inhibits the migration of human endothelial cells and tumor cells, and prevents tumor growth and invasion in animal models.

A hydrophobic cyclic peptide that acts as a potent inhibitor of MMP-2 and MMP-9 (IC₅₀ = 10 µM). Inhibits the migration of human endothelial cells and tumor cells, and prevents tumor growth and invasion in animal models. Also, phage that display this peptide specifically targets angiogenic blood vessels in vivo.

생화학적/생리학적 작용

Target IC₅₀: 10 µM against MMP-2 and MMP-9

경고

Toxicity: Standard Handling (A)

서열

H-Cys¹-Thr-Thr-His-Trp-Gly-Phe-Thr-Leu-Cys¹⁰-OH (cyclic: 1→ 10)

기타 정보

Medina, O.P., et al. 2001. Cancer Res.61, 3978.
Koivunen, E., et al. 1999. Nat. Biotechnology 17, 768.

법적 정보

Sold under license of U.S. Patent 6,624,144.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable