371545

Guanosine 5ʹ-O-(3-Thiotriphosphate), Tetralithium Salt - CAS 94825-44-2 - Calbiochem

G-protein-activating GTP analog, which is more resistant to hydrolysis than GTP.

• 동의어(들): Guanosine 5ʹ-O-(3-Thiotriphosphate), Tetralithium Salt - CAS 94825-44-2 - Calbiochem, GTPγ-S, 4Li
• 실험식(Hill 표기법): C₁₀H₁₂N₅O₁₃P₃S · 4Li
• CAS Number: 94825-44-2
• Molecular Weight: 562.98
• MDL number: MFCD00135151
• UNSPSC 코드: 12352200

속성

• 분석: ≥85% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic)
• 불순물: ≤12% GDP
• 색상: white
• solubility: water: 10 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C

설명

일반 설명

G-protein-activating GTP analog that is more resistant to hydrolysis than GTP. Has a direct stimulatory effect on Ins(1,4,5)P₃ formation in membranes.

G-protein-activating GTP analog, which is more resistant to hydrolysis than GTP. Induces exocytosis in isolated mouse pancreatic acinar cells. Also reported to stimulate insulin release from pancreatic β-cells.

생화학적/생리학적 작용

Cell permeable: no

Primary Target
G-protein-activating GTP analog

Product does not compete with ATP.

Reversible: no

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions lose about 5% of their activity after 6 months at -20°C.

기타 정보

Iino, S., et al. 2000. FEBS Lett.479, 46.
Martelli, A.M., et al. 1996. Biochem. Biophys. Res. Commun. 218, 182.
Hess, S.D., et al. 1993. Science 259, 1169.
Ekstrom, R.C., et al. 1992. J. Biol. Chem.267, 22183.
McGuirk, S.M., and Dolphin, A.C. 1992. Neurosci.49, 117.
Vaca, L., et al. 1992. Eur. J. Physiol.422, 66.
Silk, S.T., et al. 1989. J. Biol. Chem.264, 21466.
Gilman, A.G. 1987. Annu. Rev. Biochem.56, 615.
Orellana, S., et al. 1987. J. Biol. Chem..262, 1638.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable