361562

GSK-3β Inhibitor XVIII

The GSK-3β Inhibitor XVIII, also referenced under CAS 1139875-74-3, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 동의어(들): GSK-3β Inhibitor XVIII, 2-(Chloro-4-(4-thiophen-2-yl-pyrimidin-2-ylamino)-phenyl)-(4-methyl-pierazin-1-yl)-methanone
• 실험식(Hill 표기법): C₂₀H₂₀ClN₅OS
• CAS Number: 1139875-74-3
• Molecular Weight: 413.92
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥97% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: white
• solubility: DMSO: 100 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C

설명

일반 설명

A cell-permeable thienylpyrimidine compound that is reported to act as a potent and selective GSK-3β inhibitor (IC₅₀ = 64 nM), while exhibiting little or no activity against 58 and much reduced potency against 7 (>75% inhibition at 5 µM) other kinases. Shown to activate cellular Wnt pathway signaling (EC₅₀ = 1.25 µM in a Super (8X) TOPFlash reporter assay) in HEK293 cultures and promote proliferation of murine and hamster β cell lines (EC₅₀ = 1.143 µM using murine R7T1 cultures) as well as of primary rat β cells.

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

기타 정보

Wang, W., et al. 2009. Proc. Natl. Acad. Sci. USA106, 1427.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable