356790

Glyphosine

A plant growth regulator that also enhances anti-B:9-23 TCR-dependent T cell activation by modulating murine class II MHC I-Ag7-mediated B:9-23 presentation on APCs.

• 동의어(들): Glyphosine, Cp41845, N,N-bis(Phosphonomethyl)glycine, 2-(bis(Phosphonomethyl)amino)acetic acid, Polaris, Cp41845, Polaris, N,N-bis(Phosphonomethyl)glycine, 2-(bis(Phosphonomethyl)amino)acetic acid
• 실험식(Hill 표기법): C₄H₁₁NO₈P₂
• CAS Number: 2439-99-8
• Molecular Weight: 263.08
• MDL number: MFCD00056670
• UNSPSC 코드: 12352200
• 양식: solid
• 분석: ≥98% (NMR)

속성

• Quality Level: 100
• 분석: ≥98% (NMR)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic); protect from light
• 색상: white
• solubility: water: 100 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• InChI: 1S/C4H11NO8P2/c6-4(7)1-5(2-14(8,9)10)3-15(11,12)13/h1-3H2,(H,6,7)(H2,8,9,10)(H2,11,12,13)
• InChI key: OXHDYFKENBXUEM-UHFFFAOYSA-N

설명

일반 설명

A glycine-phosphonic acid compound, negatively charged at neutral pH, with immunomodulatory and anti-diabetic properties. Shown to enhance CD4⁺ T cell response to B-chain of insulin (amino acids 9-23) even at 10 nM levels (EC₅₀ = 70.6 nM). Occupies a pocket 9 of I-A^g7 (the class II molecules of the diabetes-prone NOD mice) and alters TCR/peptide-MHC affinity. Stimulates IL-10 secretion in splenocyes in non-obese diabetic (NOD) mice. Daily administration of glyphosine is shown to delay the onset of diabetes in NOD mice. Acts as a competitive inhibitor of phoshoenolpyruvate carboxylase in plants.

A plant growth regulator that also enhances anti-B:9-23 (aa 9 to 23 of insulin B chain) TCR-dependent T cell activation (EC₅₀ = 70.6 nM; EC_max = 500 nM) by modulating murine class II MHC I-A^g7-mediated B:9-23 presentation on APCs, without affecting the activation of anti-chromogranin T cells by chromogranin- I-A^g7 complex. Reported to augment B:9-23 in stimulating IL-10 production from splenocytes of diabetic NOD mice and PBMCs of type 1 diabetic individuals with HLA-DQ8, and effectively prevent the onset of diabetes in NOD mice (80 mg/kg via daily i.p.). Computer structural docking analysis indicates pocket 9 of the I-A^g7 binding groove as the glyphosine targeting site.

포장

Packaged under inert gas

경고

Toxicity: Corrosive (L)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.

기타 정보

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Michels, A.W., et al. 2011. J. Immunol.187, 5921.
Stadinski, B.D., et al. 2010. Proc. Natl. Acad. Sci. USA107, 10978.
Podesta, F.E., et al. 1987. Plant Cell Physiol.28, 375.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS05
• 신호어: Danger
• 유해 및 위험 성명서: H318
• 예방조치 성명서: P280 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable