343020

Flt-3 Inhibitor

The Flt-3 Inhibitor, also referenced under CAS 301305-73-7, controls the biological activity of Flt-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 동의어(들): Flt-3 Inhibitor
• 실험식(Hill 표기법): C₁₈H₂₀N₂O₄S
• CAS Number: 301305-73-7
• Molecular Weight: 360.43
• MDL number: MFCD00617269
• UNSPSC 코드: 12352106
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: white
• solubility: DMSO: <4 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• InChI: 1S/C18H20N2O4S/c1-23-12-8-7-10(9-13(12)24-2)17(22)20-18-15(16(19)21)11-5-3-4-6-14(11)25-18/h7-9H,3-6H2,1-2H3,(H2,19,21)(H,20,22)
• InChI key: FSPQCTGGIANIJZ-UHFFFAOYSA-N

설명

일반 설명

A cell-permeable thienylcarboxamide compound that acts as a potent, ATP-competitive, and highly selective Flt-3 inhibitor (IC₅₀ = 42 nM) with little effect against a panel of 22 other kinases (IC₅₀ ≥3 µM). Shown to exhibit antiproliferative properties against the human acute myelogenous leukemia cell line MV4-11 (IC₅₀ = 340 nM) expressing constitutively active Flt-3.

생화학적/생리학적 작용

Cell permeable: yes

Product competes with ATP.

Reversible: no

Target IC₅₀: 42 nM against Flt-3

포장

Packaged under inert gas

경고

Toxicity: Irritant (B)

기타 정보

Patch, R.J., et al. 2006. Bioorg. Med. Chem. Lett.16, 3282.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3