342000

Caspase Inhibitor, Negative Control

The Caspase Inhibitor, Negative Control, also referenced under CAS 105637-38-5, controls the biological activity of Caspase. This small molecule/inhibitor is primarily used for Cancer applications.

• 동의어(들): Caspase Inhibitor, Negative Control, Z-FA-FMK, Cathepsin B, Inhibitor I
• 실험식(Hill 표기법): C₂₁H₂₃FN₂O₄
• CAS Number: 105637-38-5
• Molecular Weight: 386.42
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated
• 색상: off-white
• solubility: DMSO: 10 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C
• InChI: 1S/C21H23FN2O4/c1-15(19(25)13-22)23-20(26)18(12-16-8-4-2-5-9-16)24-21(27)28-14-17-10-6-3-7-11-17/h2-11,15,18H,12-14H2,1H3,(H,23,26)(H,24,27)
• InChI key: ASXVEBPEZMSPHB-UHFFFAOYSA-N

설명

일반 설명

A cell-permeable, irreversible cathepsin B inhibitor that may be potentially useful in treating arthritis. Suitable as a negative control for caspase-1 inhibition studies.

A cell-permeable, irreversible cathepsin B inhibitor. Blocks LPS-induced production of IL-1α and IL-1β. Suitable as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
Cathepsin-B

Product does not compete with ATP.

Reversible: no

경고

Toxicity: Standard Handling (A)

서열

Z-Phe-Ala-FMK

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Schotte, P., et al. 2001. J. Biol. Chem.276, 21153.
Guo, H., et al. 1998. Exp. Cell Res.245, 57.
Rosenthal, P.J., et al. 1993. J. Clin. Invest.91, 1057.
Ahmed, N.K., et al. 1992. Biochem. Pharmacol.44, 1201.
Rauber, P., et al. 1986. Biochem. J. 239, 633.
Shaw, E., et al. 1986. Biomed. Biochim. Acta 45, 1397.
Rasnick, D. 1985. Anal. Biochem. 149, 461.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable