341253

FAAH Inhibitor III, URB937

• 동의어(들): FAAH Inhibitor III, URB937
• 실험식(Hill 표기법): C₂₀H₂₂N₂O₄
• Molecular Weight: 354.40
• UNSPSC 코드: 12352200

속성

• 분석: ≥95% (HPLC)
• Quality Level: 100
• 형태: powder
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: gray-white
• solubility: DMSO: 100 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C

설명

일반 설명

A blood-brain-barrier impermeable p-hydroxyphenylcarbamate compound that acts as a potent and irreversible inhibitor of FAAH activity (IC₅₀ = 26.8 nM rat brain) with excellent selectivity over monoacylglycerol lipases (IC₅₀ >100 µM). Shown to rapidly block mouse liver FAAH activity over brain (ED₅₀ = 0.2 mg/kg vs. 40 mg/kg, s.c.), elevate anandamide and palmitoylethanolamide levels in peripheral tissues (1 mg/kg, i.p.) and exert antinociceptive action. The CNS-penetrant FAAH Inhibitor II, URB597 is also available (Cat. No. 341249).

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

기타 정보

Clapper, J.R., et al. 2010. Nat. Neurosci.13, 1265.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable