208923

CaMKII Inhibitor XII

• 동의어(들): CaMKII Inhibitor XII, Ca ²⁺/Calmodulin-Dependent Protein Kinase II Inhibitor XII
• 실험식(Hill 표기법): C₂₉H₃₀ClN₅O₂S
• Molecular Weight: 548.10
• UNSPSC 코드: 12352200
• NACRES: NA.28

속성

• 분석: ≥99% (HPLC)
• Quality Level: 100
• 형태: powder
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: white
• solubility: DMSO: 100 mg/mL
• 배송 상태: wet ice
• 저장 온도: 2-8°C

설명

일반 설명

A pyrimidinyl sulfonamide compound that acts as a potent, reversible and CaM non-competitive inhibitor of CaMKII activities (IC₅₀ = 0.063 µM) with excellent selectivity over several kinases (IC₅₀ = >60, 36, 11, 30 and 21 µM for CaMKIV, MLCK, p38α, Akt1 and PKC, respectively). Shown to exhibit ~25-fold greater potency towards CaMKII than the CaM-competitive inhibitor KN-93 (Cat. No. 422708).

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

기타 정보

Asano, S., et al. 2010. Bioorg. Med. Chem. Lett.20, 6696.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable