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Merck
모든 사진(1)

Key Documents

203702

Sigma-Aldrich

Brain Derived Neurotrophic Factor, Human, Recombinant, E. coli

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About This Item

UNSPSC 코드:
12352202

분석

≥97% (HPLC)

Quality Level

형태

lyophilized

제조업체/상표

Calbiochem®

저장 조건

OK to freeze
desiccated

배송 상태

ambient

저장 온도

−20°C

일반 설명

Recombinant, human brain drived neurotrophic factor expressed in E. coli. Promotes survival and growth of neurons in the central nervous system. Sequence analysis indicates that brain derived neurotrophic factor is structurally and functionally related to nerve growth factor. mRNA for brain derived neurotrophic factor is found predominantly in the central nervous system, whereas mRNA for nerve growth factor is also found in many non-CNS tissues.
Recombinant, human brain drived neurotrophic factor expressed in E. coli. Promotes survival and growth of neurons. Structurally and functionally related to nerve growth factor. Its actions are mediated via the TrkB receptor.

생화학적/생리학적 작용

Supports survival of rat basal forebrain primary septal cultured neurons. Induces choline acetyltransferase (EC₅₀ = 50 ng/ml)

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
Reconstitute to a concentration of ≥10 µg/ml with sterile distilled H₂O or aqueous buffers. For more dilute solutions, add a stabilizing protein such as 0.1% BSA or HSA.

기타 정보

Erickson, J.T., et al. 1996. J. Neurosci. 16, 5361.
Leibrock, J., et al. 1989. Nature341, 149.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1


시험 성적서(COA)

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S M Mooney et al.
Neuroscience, 179, 256-266 (2011-02-01)
A second wave of neuronal generation occurs in the ventrobasal nucleus of the rat thalamus (VB) during the first three postnatal weeks. The present study tested the hypotheses (1) that postnatal neurogenesis in the VB is neurotrophin-regulated and (2) that
Christophe Heinrich et al.
Nature protocols, 6(2), 214-228 (2011-02-05)
Instructing glial cells to generate neurons may prove to be a strategy to replace neurons that have degenerated. Here, we describe a robust protocol for the efficient in vitro conversion of postnatal astroglia from the mouse cerebral cortex into functional

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