203325

BMS

Water-soluble reagent useful for the reduction of native disulfide bonds in proteins. Considered to be a superior reducing agent to DTT.

• 동의어(들): BMS, bis(2-Mercaptoethylsulfone)
• 실험식(Hill 표기법): C₄H₁₀O₂S₃
• CAS Number: 145626-87-5
• Molecular Weight: 186.32
• UNSPSC 코드: 12352128

속성

• Quality Level: 100
• 분석: ≥99% (titration)
• 형태: crystalline solid
• 반응 적합성: reagent type: reductant
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 색상: white
• pKa: (1) 7.9, (2) 9.0
• 배송 상태: ambient
• 저장 온도: −20°C
• InChI: 1S/C4H10O2S3/c5-9(6,3-1-7)4-2-8/h7-8H,1-4H2
• InChI key: YWXCBLUCVBSYNJ-UHFFFAOYSA-N

설명

일반 설명

Water-soluble reagent useful for the reduction of native disulfide bonds in proteins. Considered to be a superior reducing agent to DTT. Shown to reduce accessible disulfide bonds in immunoglobulin and trypsinogen under non-denaturing conditions 5 to 7 times faster than DTT at pH 7. The relatively less accessible disulfide bond in α-chymotrypsinogen A was reduced 2.3 times faster at pH 7 with BMS than with DTT. Has a pK_a of 7.9 and 9.0.

Water-soluble reagent useful for the reduction of native disulfide bonds in proteins. Considered to be a superior reducing agent to DTT. Shown to reduce accessible disulfide bonds in immunoglobulin and trypsinogen under non-denaturing conditions 5 to 7 times faster than DTT at pH 7. The relatively less accessible disulfide bond in α-chymotrypsinogen A was reduced 2.3 times faster at with BMS than with DTT at pH 7.0.

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

제조 메모

May require warming (40-45°C) to achieve complete solubilization in H₂O.

기타 정보

Singh, R., et al. 1995. Methods Enzymol.251, 167.
Singh, R., and Whitesides, G.M. 1994. Bioorg. Chem.22, 109.
Singh, R., and Whitesides, G.M. 1994. Protein Sci. 3, Suppl. 1, 430T.
Lamoureux, G.V., and Whitesides, G.M. 1993. J. Org. Chem.58, 633.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable