178223

Antipain, Dihydrochloride

Peptidyl arginine aldehyde protease inhibitor produced by actinomycetes.

• 동의어(들): Antipain, Dihydrochloride
• 실험식(Hill 표기법): C₂₇H₄₄N₁₀O₆ · 2HCl
• CAS Number: 37682-72-7
• Molecular Weight: 677.62
• MDL number: MFCD00135957
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥97% (HPLC)
• 형태: powder
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic); protect from light
• 색상: white
• solubility: water: 1 mg/mL; DMSO: 5 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• InChI: 1S/C27H44N10O6.2ClH/c1-16(2)21(34-18(15-38)10-6-12-32-25(28)29)23(40)37-22(39)19(11-7-13-33-26(30)31)35-27(43)36-20(24(41)42)14-17-8-4-3-5-9-17;;/h3-5,8-9,15-16,18-21,34H,6-7,10-14H2,1-2H3,(H,41,42)(H4,28,29,32)(H4,30,31,33)(H2,35,36,43)(H,37,39,40);2*1H/t18?,19-,20?,21-;;/m0../s1
• InChI key: GXQPAKIVOCLCHD-BXLPLHKWSA-N

설명

일반 설명

A reversible protease inhibitor produced by actinomycetes. Inhibits cathepsin A and B as well as papain, and trypsin-like serine proteases. Acts by forming a hemiacetal adduct between the aldehyde group of the inhibitor and the active proteinase. Effective at concentrations range from 1 to 100 µM.

Effective concentration: 1-100 µM.

Peptidyl arginine aldehyde protease inhibitor produced by actinomycetes. Inhibitor of Ca²⁺-dependent endopeptidases. Has specificity similar to Leupeptin (Cat. No. 108975). Inhibits trypsin-like serine proteases, papain and some cysteine proteases (IC₅₀ = 300 µM).

생화학적/생리학적 작용

Cell permeable: no

Primary Target
trypsin-like serine proteases, papain, and some cysteine proteases

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 300 µM against trypsin-like serine proteases, papain and some cysteine proteases; Effective concentration: 1-100 µM

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.

기타 정보

Lyupina, Y.V., et al. 1996. Eur. J. Pharmacol. 304, 23.
Ichikawa, S., et al. 1985. J. Reprod. Fertil.73, 385
Umezawa, H. 1976. Methods Enzymol.55, 678.
Suda, H., et al. 1972. J. Antibiot. (Tokyo) 25, 263.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable