05-23-1200

Neurotensin

Potent hypothalamic peptide neurotransmitter.

• 동의어(들): Neurotensin, NT, NTS, Pyr-LYENKPRRPYIL
• 실험식(Hill 표기법): C₇₈H₁₂₁N₂₁O₂₀
• CAS Number: 39379-15-2
• Molecular Weight: 1672.92
• UNSPSC 코드: 12352202
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥97% (HPLC)
• 형태: lyophilized solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic)
• 색상: white to off-white
• solubility: 5% acetic acid: 1 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C
• InChI: 1S/C78H121N21O20/c1-7-43(6)63(73(115)96-57(76(118)119)37-42(4)5)97-70(112)55(39-45-21-25-47(101)26-22-45)95-72(114)59-18-13-35-99(59)75(117)52(16-11-33-86-78(83)84)90-64(106)48(15-10-32-85-77(81)82)89-71(113)58-17-12-34-98(58)74(116)51(14-8-9-31-79)91-69(111)56(40-60(80)102)94-66(108)50(28-30-62(104)105)88-68(110)54(38-44-19-23-46(100)24-20-44)93-67(109)53(36-41(2)3)92-65(107)49-27-29-61(103)87-49/h19-26,41-43,48-59,63,100-101H,7-18,27-40,79H2,1-6H3,(H2,80,102)(H,87,103)(H,88,110)(H,89,113)(H,90,106)(H,91,111)(H,92,107)(H,93,109)(H,94,108)(H,95,114)(H,96,115)(H,97,112)(H,104,105)(H,118,119)(H4,81,82,85)(H4,83,84,86)
• InChI key: PCJGZPGTCUMMOT-UHFFFAOYSA-N

설명

일반 설명

Neurotensin (NT), a 13-amino acid peptide neurotransmitter encoded by the NTS gene. NT is located in the gastrointestinal tract and heterogeneously distributed in the mammalian central nervous system, and has many neurotransmitter-like characteristics. It influences various central and peripheral functions by interacting with three neurotensin receptors. It is linked to the modulation of dopaminergic systems and in the induction of changes in behavior, muscle relaxation, nociception, and hypothermia, as well as appetite, learning, memory, and fat metabolism. Moreover, it is a modulator of noradrenergic activity. It also acts as an endogenous anti-psychotic compound and lowers blood pressure, increases vascular permeability, and increases plasma levels of glucagon, glucose, growth hormone, and prolactin in rats. Additionally, it regulates the release of pituitary hormones from the brain and insulin, glucagon, and somatostatin from the gut.

생화학적/생리학적 작용

Cell permeable: no

Primary Target
Modulator of noradrenergic activity

Product does not compete with ATP.

Reversible: no

포장

Yes

경고

Toxicity: Standard Handling (A)

서열

Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH

기타 정보

Kinkead, B., et al. 1999. Biol. Psychiatr.46, 340.
Tyler, B.M., et al. 1998. Brain Res. 792, 246.
Tsuda, K., and Masuyuma, Y. 1993. Am. J. Hypertens. 6, 473.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable