추천 제품
생물학적 소스
mouse
Quality Level
항체 형태
culture supernatant
항체 생산 유형
primary antibodies
클론
Sulfo-1C-A2, monoclonal
종 반응성
human, mouse, bovine, porcine
종 반응성(상동성에 의해 예측)
all
제조업체/상표
Upstate®
기술
ELISA: suitable
immunoprecipitation (IP): suitable
western blot: suitable
동형
IgG2aκ
일반 설명
Sulfotyrosine is a common post-translational modification of secretory, plasma membrane, and lysosomal proteins. The sulfation reaction is catalyzed by specific sulfotransferase enzymes in the trans-Golgi-network. Tyrosine sulfation occurs in all multicellular organisms and up to 1% of the tyrosines in the total protein content of a cell can be sulfated. Sulfotyrosines mediates many receptor-ligand binding interactions, including the interaction of P-selectin glycoprotein ligand-1 with P-selectin, factor VIII binding to von Willebrand factor, and interactions between thrombin and hirudin. Sulfotyrosine is also involved in the entry of several parasites and viruses; for example, tyrosine sulfation of the HIV-1 co-receptor CCR5 is required for viral entry into host cells, and tyrosine sulfation of the Duffy antigen/receptor for chemokines is crucial for erythrocyte invasion by the malaria parasite Plasmodium vivax.
This clone was derived from the antibody described in Kehoe et al., 2006.
This clone was derived from the antibody described in Kehoe et al., 2006.
특이성
The antibody is predicted to recognize any sulfotyrosine, regardless of surrounding amino acid sequence.
애플리케이션
Detect Sulfotyrosine with Anti-Sulfotyrosine Antibody, Clone Sulfo-1C-A2 (Mouse Monoclonal Antibody), that has been shown to work in WB, IP, ELISA.
품질
Assayed using sulfatase treated bovine fibrinogen vs. untreated fibrinogen.
표적 설명
n/a
물리적 형태
Format: Purified
법적 정보
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Yorihiro Nishimura et al.
PLoS pathogens, 6(11), e1001174-e1001174 (2010-11-17)
Enterovirus 71 (EV71) is one of the major causative agents of hand, foot, and mouth disease, a common febrile disease in children; however, EV71 has been also associated with various neurological diseases including fatal cases in large EV71 outbreaks particularly
Isolation of HIV-1-neutralizing mucosal monoclonal antibodies from human colostrum.
Friedman, James, et al.
Testing, 7, e37648-e37648 (2012)
Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1.
Pejchal, Robert, et al.
Proceedings of the National Academy of Sciences of the USA, 107, 11483-11488 (2010)
Juan Xu et al.
PloS one, 8(3), e56114-e56114 (2013-03-09)
The latent membrane protein 1 (LMP1), which is encoded by the Epstein-Barr virus (EBV), is an important oncogenic protein that is closely related to carcinogenesis and metastasis of nasopharyngeal carcinoma (NPC), a prevalent cancer in China. We previously reported that
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