추천 제품
분석
>99% (TLC)
형태
powder
포장
pkg of 1 × 1 mg (857395P-1mg)
제조업체/상표
Avanti Research™ - A Croda Brand 857395P
지질 유형
bioactive lipids
sphingolipids
배송 상태
dry ice
저장 온도
−20°C
SMILES string
CCCCCCCCCCCCCCC1=C(C1)[C@@H](O)[C@@H](NC(CCCCCCC)=O)CO
일반 설명
GT-11 is also termed as C8-cyclopropenylceramide or C8-CPPC.
생화학적/생리학적 작용
GT-11 is an inhibitor of dihydroceramides (DHCer) desaturase activity.
포장
5 mL Amber Glass Screw Cap Vial (857395P-1mg)
법적 정보
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Gemma Triola et al.
Molecular pharmacology, 66(6), 1671-1678 (2004-09-17)
Dihydroceramide desaturase catalyzes the conversion of the innocuous precursor dihydroceramide into a highly bioactive product ceramide. We studied the effect of N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide (GT11), the first inhibitor of this enzyme, in primary cultured cerebellar neurons. Although desaturase was efficiently inhibited (IC50
Inhibition of sphingolipid metabolism enhances resveratrol chemotherapy in human gastric cancer cells
Shin K, et al.
Biomolecules & Therapeutics, 20(5), 470-470 (2012)
Bioactive sphingolipids: An overview on ceramide, ceramide 1-phosphate dihydroceramide, sphingosine, sphingosine 1-phosphate
Handbook of Neurochemistry and Molecular Neurobiology:Neural Lipids, 373-383 (2010)
Pau Muñoz-Guardiola et al.
Autophagy, 17(6), 1349-1366 (2020-05-14)
ABTL0812 is a first-in-class small molecule with anti-cancer activity, which is currently in clinical evaluation in a phase 2 trial in patients with advanced endometrial and squamous non-small cell lung carcinoma (NCT03366480). Previously, we showed that ABTL0812 induces TRIB3 pseudokinase
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