추천 제품
분석
>99% (TLC)
형태
powder
포장
pkg of 1 × 1 mg (857390P-1mg)
pkg of 1 × 10 mg (857390P-10mg)
제조업체/상표
Avanti Research™ - A Croda Brand 857390P
지질 유형
sphingolipids
배송 상태
dry ice
저장 온도
−20°C
일반 설명
Compound 2a is a selective antagonist for human S1P1 (hS1P1) receptor activation by the physiological agonist S1P.
W146 is a sphingosine-1-phosphate 1 (S1P1) selective antagonist.
애플리케이션
W146 has been used:
- to verify the mode of action of sphingosine-1-phosphate (S1P) in human bone marrow derived mesenchymal stem cells (hMSCs ) and primary human hepatogenic profibrotic cells (hHPCs)
- to study oxidative stress and drug treatment in granulosa cells
- to evaluate its effects on transendothelial electrical resistance (TEER)
생화학적/생리학적 작용
W146 acts as an orthosteric antagonist. It is linked to blood lymphopenia and lung edema in mice.
포장
5 mL Amber Glass Screw Cap Vial (857390P-10mg)
5 mL Amber Glass Screw Cap Vial (857390P-1mg)
법적 정보
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
No data available
Flash Point (°C)
No data available
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
The sphingosine-1-phosphate receptor-1 antagonist, W146, causes early and short-lasting peripheral blood lymphopenia in mice
Sphingosine-1-Phosphate Signaling in Immunology and Infectious Diseases (2014)
S1P, dihydro-S1P and C24: 1-ceramide levels in the HDL-containing fraction of serum inversely correlate with occurrence of ischemic heart disease
Argraves KM, et al.
Lipids in Health and Disease, 10(1), 70-70 (2011)
Sphingosine-1-phosphate inhibits H2O2-induced granulosa cell apoptosis via the PI3K/Akt signaling pathway
Nakahara T, et al.
Fertility and Sterility, 98(4) (2012)
M Germana Sanna et al.
Nature chemical biology, 2(8), 434-441 (2006-07-11)
Sphingosine 1-phosphate (S1P, 1) regulates vascular barrier and lymphoid development, as well as lymphocyte egress from lymphoid organs, by activating high-affinity S1P1 receptors. We used reversible chemical probes (i) to gain mechanistic insights into S1P systems organization not accessible through
Kelley M Argraves et al.
The Journal of biological chemistry, 283(36), 25074-25081 (2008-07-09)
High density lipoproteins (HDL) are major plasma carriers of sphingosine 1-phosphate (S1P). Here we show that HDL increases endothelial barrier integrity as measured by electric cell substrate impedance sensing. S1P was implicated as the mediator in this process through findings
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