QBD10011

Phthalimidooxy-dPEG^®₄-NHS ester

• 실험식(Hill 표기법): C₂₃H₂₈N₂O₁₁
• Molecular Weight: 508.48
• MDL number: MFCD28155511
• UNSPSC 코드: 12352108
• PubChem Substance ID: 329823874
• NACRES: NA.22

속성

• 분석: >90%
• 형태: solid or viscous liquid
• 반응 적합성: reactivity: amine reactive; reagent type: cross-linking reagent; reactivity: thiol reactive
• 작용기: NHS ester
• 폴리머 구조: shape: linear; functionality: heterobifunctional
• 배송 상태: ambient
• 저장 온도: −20°C
• SMILES string: O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCON2C(C(C=CC=C3)=C3C2=O)=O

설명

특징 및 장점

Phthalimidooxy-dPEG^®₄-NHS ester allows introduction of an oxyamine function onto a target molecule for cross-linking proteins or for creating stable conjugates with the target molecule. The oxyamine function is protected by a phthalimido protecting group on one end of the spacer arm, and the spacer is installed on the target molecule with the amine-reactive N-hydroxysuccinimide (NHS) group on the other end of the spacer. The single molecular weight dPEG^® spacers have precise length for spatial control. They are hydrophilic and non-immunogenic. The dPEG^® spacers improve water solubility and reduce aggregation and precipitation of proteins. The phthalimido protecting group can be removed using hydrazine. The oxyamine group exposed after deprotection can be reacted with an aldehyde- or ketone-containing molecule to form an oxime bond linking the two molecules. These reagents can be used with any protein, peptide, or small molecule that has a free amine.

법적 정보

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable