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Merck
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934178

Sigma-Aldrich

TissueFab® bioink 

(GelHAHep)MA Vis/405 nm, low endotoxin

동의어(들):

3D Bioprinting, Bioink, Controlled Release, GelMA, Gelatin, Gelatin Methacryloyl, HAMA, Heparin, Heparin Methacrylate, Hyaluronan, Hyaluronic Acid, Hyaluronic Acid Methacrylate, Hydrogel

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About This Item

UNSPSC 코드:
12352201
NACRES:
NA.28

Quality Level

100

무균

0.2 μm filtered

양식

gel form

포함

<50 EU/mL Endotoxin

구성

Gelatin, Hyaluronic acid, Heparin, Alginate

불순물

<5 CFU/g Bioburden ( fungal)
<5 CFU/g Bioburden (Total Aerobic)

색상

pale yellow to colorless

pH

6.5-7.5

호환성

3D bioprinting, extrusion bioprinting

저장 온도

2-8°C

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관련 카테고리

일반 설명

TissueFab® bioink -(GelHAHep)MA Vis/405 nm, low endotoxin formulation can be used to bioprint cell-laden hydrogels in the desired shape without any supporting material. This bioink can be crosslinked in one step using exposure to 405 nm light for further culture and maturation of cells for tissue engineering and regenerative medicine applications.

애플리케이션

Currently, there is a need for high-quality, commercially available ready-to-use bioink formulations to enable the reproducible fabrication of synthetic tissues and organs by 3D Bioprinting
  • drug discovery
  • in-vitro disease models
  • regenerative medicine-cell-cultured meat

특징 및 장점

  • Bioprinting models replicate biology for drug discovery and in vivo applications
  • Sterile, low endotoxin-Batch control offers reproducible models for preclinical toxicology testing and drug screening
  • Extended shelf-life & stability

기타 정보

Heparin is a naturally occurring linear biopolymer and highly sulfated glycosaminoglycan (GAG). Research has demonstrated that heparin can modulate binding extracellular matrix proteins and sequester growth factors and cytokines, making them useful in 3D applications.

The methacrylate-functionalization of heparin allows thermal or photochemical crosslinking via covalent conjugation. Heparins exhibit high anionic charge densities to promote large swelling ratios in water. Heparin-based bioinks are used in tissue engineering, 3D bio-printing, and drug delivery applications.

Gelatin methacryloyl (GelMA) is a polymerizable hydrogel material derived from natural extracellular matrix (ECM) components. Due to its low cost, abundance, and retention of natural cell binding motifs, gelatin has become a highly sought material for tissue engineering applications. The addition of photocrosslinkable methacrylamide functional groups in GelMA allows the synthesis of biocompatible, biodegradable, and non-immunogenic hydrogels that are stable in biologically relevant conditions and promote cell adhesion, spreading, and proliferation.

Hyaluronic acid (HA) is a linear polysaccharide of alternating D-glucuronic acid/N-acetyl-D-glucosamine found primarily in connective tissues. HA-based hydrogels are prevalent in tissue engineering, 3D bioprinting, and drug delivery applications. The methacrylate (MA) functionalized hyaluronic acid is photo-cross-linkable.

Low Endotoxin, low bioburden: Endotoxins can negatively impact cellular growth, morphology, differentiation, inflammation, and protein expression. The bioburden is the number of contaminated organisms found in a given amount of material.

We test each lot for endotoxins in addition to total bioburden (aerobic and fungal) to minimize unwanted interactions. For more information: Cell Culture FAQs: Bacterial Endotoxin Contamination

법적 정보

TISSUEFAB is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Cailing Zhao et al.
Biomacromolecules, 22(6), 2729-2739 (2021-06-01)
Extrusion-based bioprinting is an emerging and most frequently used technique for the fabrication of cell-laden constructs. A suitable hydrogel-based bioink for cell encapsulation and protection is critical for printability, structural stability, and post-printing cell viability. The thiol-ene chemistry-based gelatin-norbornene (GelNB)
Liliang Ouyang et al.
Science advances, 6(38) (2020-09-20)
A major challenge in three-dimensional (3D) bioprinting is the limited number of bioinks that fulfill the physicochemical requirements of printing while also providing a desirable environment for encapsulated cells. Here, we address this limitation by temporarily stabilizing bioinks with a
Danielle S W Benoit et al.
Biomaterials, 28(1), 66-77 (2006-09-12)
Poly(ethylene glycol) (PEG) hydrogels functionalized with heparin were utilized as a three-dimensional culture system for human mesenchymal stem cells (hMSCs). Heparin-functionalized hydrogels supported hMSC viability, as quantified through live/dead imaging, and induced osteogenic differentiation, as measured by increased alkaline phosphatase
Jingming Chen et al.
Biomedical materials (Bristol, England), 15(4), 045006-045006 (2019-08-31)
The ideal combination of hydrogel components for regeneration of cartilage and cartilaginous interfaces is a significant challenge because control over differentiation into multiple lineages is necessary. Stabilization of the phenotype of stem cell derived chondrocytes is needed to avoid undesired
Yingkai Liang et al.
Acta biomaterialia, 10(4), 1588-1600 (2013-08-06)
Heparin plays an important role in many biological processes via its interaction with various proteins, and hydrogels and nanoparticles comprising heparin exhibit attractive properties, such as anticoagulant activity, growth factor binding, and antiangiogenic and apoptotic effects, making them great candidates
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