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Merck
모든 사진(1)

문서

900660

Sigma-Aldrich

Poly(D,L-lactide)-b-poly(ethylene glycol)-b-poly(D,L-lactide)

5k-2k-5k

동의어(들):

PLA-PEG-PLA, PLA-PEG-PLA triblock copolymer

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About This Item

Linear Formula:
HO(CH(CH3)COO)m(CH2CH2O)n(COCH(CH3)O)mH
UNSPSC 코드:
12162002

형태

solid

저장 온도

2-8°C

애플리케이션

Biocompatible, amphiphilic triblock polymer composed of a hydrophilic, central PEG block and two terminal hydrophobic poly(D,L-lactide) (PLA) blocks. These materials have been used in controlled release formulation and nanoparticle formation for drug delivery applications. Well-defined materials with varying properties can be prepared by controlling the relative length of each polymer block. Hydroxyl termination allows for facile further chemical modification of these materials.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

Kun Shi et al.
Scientific reports, 6, 19077-19077 (2016-01-12)
In this study, a series of injectable thermoreversible and thermogelling PDLLA-PEG-PDLLA copolymers were developed and a systematic evaluation of the thermogelling system both in vitro and in vivo was performed. The aqueous PDLLA-PEG-PDLLA solutions above a critical gel concentration could
H Danafar et al.
Pharmaceutical development and technology, 22(8), 947-957 (2016-01-08)
A conjugate of the antihypertensive drug, lisinopril, with triblock poly(lactic acid)-poly(ethylene glycol)-poly(lactic acid) (PLA-PEG-PLA) copolymer was synthesized by the reaction of PLA-PEG-PLA copolymer with lisinopril in the presence of dicyclohexylcarbodiimide and dimethylaminopyridine. The conjugated copolymer was characterized in vitro by
Mesoscale simulation and experimental studies of self-assembly behavior of a PLA-PEG-PLA triblock copolymer micelle for sustained drug delivery.
Chansuna M, et al.
Journal of Polymer Research, 21(6), 452-452 (2014)

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