모든 사진(1)
About This Item
실험식(Hill 표기법):
C10H16N2O2
CAS Number:
Molecular Weight:
196.25
MDL number:
UNSPSC 코드:
12352005
PubChem Substance ID:
NACRES:
NA.22
추천 제품
분석
97%
광학 활성
[α]20/D −105.5°, c = 1 in chloroform
mp
33-36 °C (lit.)
SMILES string
CC(C)(C)OC(=O)N1CCC[C@H]1C#N
InChI
1S/C10H16N2O2/c1-10(2,3)14-9(13)12-6-4-5-8(12)7-11/h8H,4-6H2,1-3H3/t8-/m0/s1
InChI key
MDMSZBHMBCNYNO-QMMMGPOBSA-N
애플리케이션
Used in synthesis of prolyl oligopeptidase inhibitors.
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point (°F)
230.0 °F - closed cup
Flash Point (°C)
110 °C - closed cup
개인 보호 장비
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Janice Lawandi et al.
Journal of medicinal chemistry, 52(21), 6672-6684 (2009-11-06)
Prolyl oligopeptidases cleave peptides on the carboxy side of internal proline residues and their inhibition has potential in the treatment of human brain disorders. Using our docking program fitted, we have designed a series of constrained covalent inhibitors, built from
Erik A A Wallén et al.
Journal of medicinal chemistry, 46(21), 4543-4551 (2003-10-03)
Isophthalic acid bis(l-prolyl-pyrrolidine) amide is a very potent prolyl oligopeptidase inhibitor, but it has a log P value of -0.2, which is very low for a compound targeted to the brain. Therefore, these types of compounds were further modified to
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