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Merck
모든 사진(2)

문서

412422

Sigma-Aldrich

PAMAM dendrimer, ethylenediamine core, generation 3.0 solution

20 wt. % in methanol

동의어(들):

Starburst PAMAM-G 3

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About This Item

Linear Formula:
[NH2(CH2)2NH2]:(G=3);dendri PAMAM(NH2)32
CAS Number:
Molecular Weight:
6908.84
MDL number:
UNSPSC 코드:
12162002
NACRES:
NA.23

설명

amino surface groups

형태

liquid

분자량

generation 3.0

특징

core type ethylenediamine core (2-carbon core)

농도

20 wt. % in methanol

표면기 개수

32

refractive index

n20/D 1.367

bp

64.7 °C

density

0.863 g/mL at 25 °C

저장 온도

2-8°C

일반 설명

PAMAM dendrimer is a symmetrical polymer with a large number of terminal groups that can easily bind to biomolecules due to their biocompatibility and affinity. These dendrimers have a multivalent surface that contains envelopes and various active sites at the core with the attached dendrons. They are highly branched nanoscale polymers that are extensively used in the field of biomedicine for targeted drug delivery.

애플리케이션

PAMAM dendrimers can be used as transfection agents for the delivery of nucleic acids. For example, it can be used in the pulmonary delivery of siRNA directed against tumor necrosis factor (TNF).

물리적 형태

Contains 32 surface primary amino groups

법적 정보

Manufactured by Dendritech®, Inc.
Dendritech is a registered trademark of Dendritech, Inc.

픽토그램

FlameSkull and crossbonesHealth hazard

신호어

Danger

유해 및 위험 성명서

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

표적 기관

Eyes,Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point (°F)

51.8 °F - closed cup

Flash Point (°C)

11 °C - closed cup


시험 성적서(COA)

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문서 라이브러리 방문

Polyamidoamine dendrimers: Favorable polymeric nanomaterials for lipase activation
Amal A.M. Elgharbawy, et al.
Materials Today Communications, 25, 101492-101492 (2020)
Treatment of acute lung inflammation by pulmonary delivery of anti-TNF-? siRNA with PAMAM dendrimers in a murine model
Adam Bohr, et al.
European Journal of Pharmaceutics and Biopharmaceutics, 156, 114-120 (2020)
Ajay Vikram Singh et al.
ACS applied materials & interfaces, 13(1), 1943-1955 (2020-12-30)
In an in vitro nanotoxicity system, cell-nanoparticle (NP) interaction leads to the surface adsorption, uptake, and changes into nuclei/cell phenotype and chemistry, as an indicator of oxidative stress, genotoxicity, and carcinogenicity. Different types of nanomaterials and their chemical composition or

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