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Merck
모든 사진(1)

주요 문서

모든 문서 보기

372714

Sigma-Aldrich

2,6-Dimethoxypyridine-3-carboxylic acid

99%

동의어(들):

2,6-Dimethoxynicotinic acid

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C8H9NO4
CAS Number:
16727-43-8
Molecular Weight:
183.16
MDL number:
MFCD00075582
UNSPSC 코드:
12352100
PubChem Substance ID:
24863158

분석

99%

mp

140-144 °C (lit.)

SMILES string

COc1ccc(C(O)=O)c(OC)n1

InChI

1S/C8H9NO4/c1-12-6-4-3-5(8(10)11)7(9-6)13-2/h3-4H,1-2H3,(H,10,11)

InChI key

SDJQZCSCHUIITF-UHFFFAOYSA-N

일반 설명

2,6-Dimethoxypyridine-3-carboxylic acid (2,6-Dimethoxynicotinic acid, DMNIH) is a piperidine derivative. It forms various organotin(IV) complexes and their antiproliferative action against pancreatic carcinoma (PANC-1), erythroleukemia (K562), and two glioblastoma multiform (U87 and LN-229) human cell lines has been evaluated.

애플리케이션

2,6-Dimethoxypyridine-3-carboxylic acid (2,6-Dimethoxynicotinic acid, DMNIH) may be used in the preparation of the following organotin(IV) complexes (DMNIH=2,6-dimethoxynicotinic acid, BZDOH=1,4-benzodioxane-6-carboxylic acid, DMFUH=2,5-dimethyl-3-furoic acid and Cy=cyclohexyl):
  • [SnCy3-(DMNI)]
  • [SnCy3(BZDO)]
  • [SnCy3(DMFU)]
  • [SnPh2-(BZDO)2]
2,6-Dimethoxypyridine-3-carboxylic acid (2,6-dimethoxynicotinic acid, DMPH) may be used in the preparation of novel benzothiazolo naphthyridone carboxylic acid derivatives. It may be used in the preparation of following complexes, via reaction with different precursors [Ti(η5-C5H5)2Cl2], [Ti(η5-C5H4Me)2Cl2], [Ti(η5-C5H4SiMe3)(η5-C5H5)Cl2], [Ti(η5-C5Me5)Cl3], SnMe3Cl and GatBu3:
  • [Ti(η5-C5H5)2(DMP-κO)2]
  • [Ti(η5-C5H4Me)2(DMP-κO)2]
  • [Ti(η5-C5H4SiMe3)(η5-C5H5)(DMP-κO)2
  • [Ti(η5-C5Me5)(DMP-κ2O,O′)3]
  • [SnMe3(μ-DMP-κO:κO′)]∞
  • [GatBu2(μ-DMP-κO:κO′)]2

픽토그램

Exclamation mark
GHS07

신호어

Warning

유해 및 위험 성명서

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

표적 기관

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves

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시험 성적서(COA)

Lot/Batch Number
55096MJ
04630DJ
10518BJ
00725MH
08005MH

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문서 라이브러리 방문

One ligand different metal complexes: Biological studies of titanium (IV), tin (IV) and gallium (III) derivatives with the 2, 6-dimethoxypyridine-3-carboxylato ligand.
Gomez-Ruiz S, et al.
Journal of Organometallic Chemistry, 696(20), 3206-3213 (2011)
Murugesan Dinakaran et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 63(1), 11-18 (2007-12-15)
Sixteen novel 3-nitro-2-(sub)-5,12-dihydro-5-oxobenzothiazolo[3,2-a]-1,8-naphthyridine-6-carboxylic acids were synthesized from 2,6-dimethoxynicotinic acid and 2-aminothiophenol and evaluated for their antitubercular activities in vitro and in vivo against Mycobacterium tuberculosis H(37) Rv (MTB) and multi-drug resistant M. tuberculosis (MDR-TB). Among the synthesized compounds, 2-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-3-nitro-5,12-dihydro-5-oxobenzothiazolo[3,2-a]-1,8-naphthyridine-6-carboxylic acid
Lourdes Rocamora-Reverte et al.
ChemMedChem, 7(2), 301-310 (2011-12-16)
A group of organotin(IV) complexes were prepared: [SnCy3 (DMNI)] (1), [SnCy3 (BZDO)] (2), [SnCy3 (DMFU)] (3), and [SnPh2 (BZDO)2 ] (4), for which DMNIH=2,6-dimethoxynicotinic acid, BZDOH=1,4-benzodioxane-6-carboxylic acid, and DMFUH=2,5-dimethyl-3-furoic acid. The cytotoxic activities of compounds 1-4 were tested against pancreatic

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