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365602

Sigma-Aldrich

Sinomenine

0.3 mol chloroform of crystallization

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About This Item

실험식(Hill 표기법):
C19H23NO4 · 0.3CHCl3
CAS Number:
115-53-7
Molecular Weight:
365.20
MDL number:
MFCD00134303
UNSPSC 코드:
12352005
PubChem Substance ID:
24862546
NACRES:
NA.22

약물 제어

regulated under CDSA - not available from Sigma-Aldrich Canada

불순물

0.3 mol chloroform of crystallization

mp

180 °C (dec.) (lit.)

작용기

ether
ketone

SMILES string

COC1=CC2[C@@H]3Cc4ccc(OC)c(O)c4[C@]2(CCN3C)CC1=O

InChI

1S/C19H23NO4/c1-20-7-6-19-10-14(21)16(24-3)9-12(19)13(20)8-11-4-5-15(23-2)18(22)17(11)19/h4-5,9,12-13,22H,6-8,10H2,1-3H3/t12-,13+,19-/m1/s1

InChI key

INYYVPJSBIVGPH-QHRIQVFBSA-N

유사한 제품을 찾으십니까? 방문 제품 비교 안내

픽토그램

Health hazardExclamation mark
GHS08,GHS07

신호어

Danger

유해 및 위험 성명서

H302,H315,H319,H335,H351,H361d,H372

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

표적 기관

Liver,Kidney, Respiratory system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
16127DZ
07415CU
03216DY

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문서 라이브러리 방문

Meng-Xiang Su et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 889-890, 39-43 (2012-02-22)
A sensitive and selective liquid chromatographic tandem mass spectrometric method was developed and validated for the determination of sinomenine in human plasma. Plasma samples were precipitated using methanol with metronidazole as internal standard. Separation was carried out on an Inertsil
Peng Teng et al.
European journal of medicinal chemistry, 50, 63-74 (2012-02-14)
Sinomenine (1) is clinically available for the treatment of rheumatoid arthritis (RA), however, its efficacy is quite weak. In the present study, a library of novel sinomenine-based homodimers and monomers through variable-length linkers were designed and synthesized, and their bioactivities
Yi Hong et al.
Cancer immunology, immunotherapy : CII, 62(3), 447-454 (2012-09-04)
Transferrin receptor (TfR) has been used as a target for the antibody-based therapy of cancer due to its higher expression in tumors relative to normal tissues. Great potential has been shown by anti-TfR antibodies combined with chemotherapeutic drugs as a
Mei-Yu Zhang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(4), 597-604 (2013-05-30)
To observe the analgesic effect of sinomenine on the neuropathic pain rat model induced by SSNI, and discuss its impact on monoamine neurotransmitters in striatal extracellular fluid. Male SD rats were randomly divided into the sham operation group, the SSNI
Y C Oh et al.
European review for medical and pharmacological sciences, 16(9), 1184-1191 (2012-10-11)
Sinomenine is an alkaloid compound and a prominent anti-inflammatory agent found in the root of the climbing plant Sinomenium acutum. However, its effects on the mechanism of human mast cell line (HMC)-1-mediated inflammation remained unknown. To provide insight into the
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