188204

p-Toluenesulfonylmethyl isocyanide

98%

• 동의어(들): (p-Tolylsulfonyl)methyl isocyanide, TosMIC, Tosylmethyl isocyanide
• Linear Formula: CH₃C₆H₄SO₂CH₂NC
• CAS Number: 36635-61-7
• Molecular Weight: 195.24
• Beilstein: 3592382
• EC Number: 253-140-1
• MDL number: MFCD00000005
• UNSPSC 코드: 12352100
• PubChem Substance ID: 24851306
• NACRES: NA.22

속성

• 분석: 98%
• 형태: solid
• mp: 109-113 °C (lit.)
• solubility: water: slightly soluble
• 저장 온도: 2-8°C
• SMILES string: Cc1ccc(cc1)S(=O)(=O)C[N+]#[C-]
• InChI: 1S/C9H9NO2S/c1-8-3-5-9(6-4-8)13(11,12)7-10-2/h3-6H,7H2,1H3
• InChI key: CFOAUYCPAUGDFF-UHFFFAOYSA-N

설명

일반 설명

p-Toluenesulfonylmethyl isocyanide undergoes base-promoted 1,3-dipolar cycloaddition reaction with immobilized imines under microwave irradiation to yield 1,5-disubstituted imidazoles. It is a versatile synthon in organic chemistry, extensively used for the synthesis of heterocyclic compounds.

애플리케이션

p-Toluenesulfonylmethyl isocyanide was used:

• in the synthesis of triplet drugs with the 1,3,5-trioxazatriquinane skeleton
• as reagent in the preparation of biologically active pyrroles and imidazoles
• as the isonitrile component in a diastereoselective Passerini reaction employing sugar-derived aldehydes

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H300 + H310 + H330
• 예방조치 성명서: P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
• 보충제 위험성: EUH032
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges