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Merck
모든 사진(3)

문서

144185

Sigma-Aldrich

2,4-Dichloro-6-methylpyrimidine

98%

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모든 사진(3)

About This Item

실험식(Hill 표기법):
C5H4Cl2N2
CAS Number:
5424-21-5
Molecular Weight:
163.00
EC Number:
226-563-4
MDL number:
MFCD00006064
UNSPSC 코드:
12352100
PubChem Substance ID:
24848638
NACRES:
NA.22

분석

98%

형태

solid

bp

219 °C (lit.)

mp

44-47 °C (lit.)

SMILES string

Cc1cc(Cl)nc(Cl)n1

InChI

1S/C5H4Cl2N2/c1-3-2-4(6)9-5(7)8-3/h2H,1H3

InChI key

BTLKROSJMNFSQZ-UHFFFAOYSA-N

일반 설명

2,4-Dichloro-6-methylpyrimidine undergoes double cross-coupling reaction with 2-(tributylstannyl)pyridine, followed by aldol condensation to yield 4-arylvinyl-2,6-di(pyridin-2-yl)pyrimidines. It reacts with 1H,1H,2H,2H-perfluorodecanethiol during fluorous synthesis of disubstituted pyrimidines.

애플리케이션

2,4-Dichloro-6-methylpyrimidine was used in the synthesis of (2-chloro-6-methyl-pyrimidin-4-yl)-(2,3-dihydro-benzothiazol-6-yl)-amine.

픽토그램

Corrosion
GHS05

신호어

Danger

유해 및 위험 성명서

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point (°F)

235.4 °F - closed cup

Flash Point (°C)

113 °C - closed cup

개인 보호 장비

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

시험 성적서(COA)

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문서 라이브러리 방문

Caroline Hadad et al.
The Journal of organic chemistry, 76(10), 3837-3845 (2011-04-06)
A series of 4-arylvinyl-2,6-di(pyridin-2-yl)pyrimidines have been efficiently prepared by a double cross-coupling reaction between 2,4-dichloro-6-methylpyrimidine and 2-(tributylstannyl)pyridine, followed by aldol condensation with the appropriate aromatic aldehyde substituted with electron-donating, electron-withdrawing, dendritic, or water-soluble groups. The effect of different protic and
Eliud Hernández et al.
Puerto Rico health sciences journal, 29(4), 348-356 (2011-01-26)
Rho family GTPases are molecular switches that control signaling pathways regulating a myriad of cellular functions. Rac1, a Rho family member, plays a critical role in several aspects of tumorigenesis, cancer progression, invasion, and metastasis. Rac proteins are not mutated
Wei Zhang
Organic letters, 5(7), 1011-1013 (2003-03-28)
[reaction: see text] The fluorous synthesis of disubstituted pyrimidines is carried out by attaching 2,4-dichloro-6-methylpyrimidine with 1H,1H,2H,2H-perfluorodecanethiol. The tagged substrate is substituted with 3-(trifluoromethyl)pyrazole followed by thioether oxidation and tag displacement with amines or thiols. The fluorous chain serves as

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