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Merck

TOP2A

topoisomerase (DNA) II alpha 170kDa

동의어:
TOP2, TP2A
종:
Human TOP2A (7153), Mouse Top2a (21973), Rat Top2a (360243), dog TOP2A (480525), Domestic Rabbit TOP2A (100357676), Zebrafish top2a (323733), chicken TOP2A (395570), sheep TOP2A (101108762), domestic guinea pig Top2a (100730168), cow TOP2A (787696)
UniProtKB ID:
P11388, B2RTS1, Q71UN1, Q71UQ5, Q9HB24, Q9HB25, Q9HB26, Q9UP44
Clone ID:
  • Human(7153) Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]
  • Mouse(21973) topoisomerase (DNA) II alpha
  • Rat(360243) topoisomerase (DNA) II alpha
  • dog(480525) topoisomerase (DNA) II alpha 170kDa
  • Domestic Rabbit(100357676) topoisomerase (DNA) II alpha 170kDa
  • Zebrafish(323733) topoisomerase (DNA) II alpha
  • chicken(395570) topoisomerase (DNA) II alpha 170kDa
  • sheep(101108762) topoisomerase (DNA) II alpha 170kDa
  • domestic guinea pig(100730168) topoisomerase (DNA) II alpha 170kDa
  • cow(787696) topoisomerase (DNA) II alpha 170kDa
  • domestic cat(101083813) topoisomerase (DNA) II alpha 170kDa

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Antibodies

제품 번호
설명
종별 반응성
응용분야
SAB5702379
Anti-DNA topoisomerase II alpha (TOP2A) Antibody, clone 8V9C8, Rabbit Monoclonal, ,
종별 반응성
mouse
응용분야
western blot
MAB4197
Anti-Topoisomerase II Antibody, clone KiS1, clone KiS1, Chemicon®, from mouse,
종별 반응성
human
응용분야
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
SAB4502998
Anti-TOP2A antibody produced in rabbit, affinity isolated antibody,
종별 반응성
human
응용분야
ELISA
immunofluorescence
immunohistochemistry
western blot
SAB4502996
Anti-TOP2A antibody produced in rabbit, affinity isolated antibody,
종별 반응성
human
응용분야
ELISA
western blot
HPA006458
Anti-TOP2A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab1,
종별 반응성
human
응용분야
immunohistochemistry
western blot

Small Molecule - Inhibitor

제품 번호
설명
종
D2975000
Doxorubicin hydrochloride, European Pharmacopoeia (EP) Reference Standard,
종
human
1225703
Doxorubicin hydrochloride, United States Pharmacopeia (USP) Reference Standard,
종
human
PHR1789
Doxorubicin Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material,
종
human
44583
Doxorubicin hydrochloride, suitable for fluorescence, 98.0-102.0% (HPLC),
종
human
D1515
Doxorubicin hydrochloride, 98.0-102.0% (HPLC),
종
human

Proteins

제품 번호
설명
종
T8944
Topoisomerase II α human, (Single band on SDS-PAGE), liquid,
종
human

esiRNA

제품 번호
설명
종
EHU073241
MISSION® esiRNA, targeting human TOP2A,
종
human
EMU058411
MISSION® esiRNA, targeting mouse Top2a,
종
mouse