SHH
sonic hedgehog
동의어:
HHG1, HLP3, HPE3, MCOPCB5, SMMCI, TPT, TPTPS
종:
Human SHH (6469), Mouse Shh (20423), Rat Shh (29499), chicken SHH (395615), domestic cat SHH (100169727), dog SHH (608860), sheep SHH (101117666), sheep SHH (780492), cow SHH (286821), Domestic Rabbit SHH (100352774) ...더
UniProtKB ID:
Clone ID:
- Human(6469) Summary: This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly. [provided by RefSeq, Jul 2008]
- Mouse(20423) sonic hedgehog
- Rat(29499) sonic hedgehog
- chicken(395615) sonic hedgehog
- domestic cat(100169727) sonic hedgehog
- dog(608860) sonic hedgehog
- sheep(101117666) sonic hedgehog
- sheep(780492) sonic hedgehog
- cow(286821) sonic hedgehog
- Domestic Rabbit(100352774) sonic hedgehog
- domestic guinea pig(100732014) sonic hedgehog
- naked mole-rat(101719896) sonic hedgehog
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
ELISA
Antibodies
제품 번호
설명
종별 반응성
응용분야
Anti-Sonic Hedgehog peptide (C-terminal) antibody produced in goat, affinity isolated antibody, lyophilized powder,
종별 반응성
mouse
응용분야
immunohistochemistry
western blot
western blot
Anti-Sonic Hedgehog (Shh) antibody produced in rabbit, ,
종별 반응성
human, mouse, rat
응용분야
immunohistochemistry
western blot
western blot
Anti-Sonic Hedgehog Antibody, from rabbit, purified by affinity chromatography,
종별 반응성
human, mouse
응용분야
immunohistochemistry
western blot
western blot
Anti-SHH, affinity isolated antibody,
종별 반응성
dog, guinea pig, horse, human, mouse, rabbit, rat
응용분야
immunohistochemistry
western blot
western blot
Anti-Sonic Hedgehog antibody, Mouse monoclonal, clone SH154, purified from hybridoma cell culture,
종별 반응성
human, mouse, rat
응용분야
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Proteins
제품 번호
설명
종
Sonic Hedgehog human, Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture,
종
human
Sonic Hedgehog Peptide from mouse, ≥97% (SDS-PAGE), recombinant, expressed in E. coli, Fused to a histidine tag at the C-terminus, lyophilized powder,
종
mouse