INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
동의어:
SHIP, SHIP-1, SHIP1, SIP-145, hp51CN
종:
Human INPP5D (3635), Mouse Inpp5d (16331), Rat Inpp5d (54259), chicken INPP5D (424745), Zebrafish inpp5d (559103), naked mole-rat Inpp5d (101711777), domestic guinea pig Inpp5d (100722743), sheep INPP5D (101112941), Horse INPP5D (100064896), cow INPP5D (507329) ...더
UniProtKB ID:
Clone ID:
- Human(3635) Summary: This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
- Mouse(16331) inositol polyphosphate-5-phosphatase D
- Rat(54259) inositol polyphosphate-5-phosphatase D
- chicken(424745) inositol polyphosphate-5-phosphatase, 145kDa
- Zebrafish(559103) inositol polyphosphate-5-phosphatase, 145kDa
- naked mole-rat(101711777) inositol polyphosphate-5-phosphatase, 145kDa
- domestic guinea pig(100722743) inositol polyphosphate-5-phosphatase, 145kDa
- sheep(101112941) inositol polyphosphate-5-phosphatase, 145kDa
- Horse(100064896) inositol polyphosphate-5-phosphatase, 145kDa
- cow(507329) inositol polyphosphate-5-phosphatase, 145kDa
- domestic cat(101100500) inositol polyphosphate-5-phosphatase, 145kDa
- dog(100688270) inositol polyphosphate-5-phosphatase, 145kDa
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Antibodies
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human, mouse, rat
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ELISA
western blot
western blot
Anti-SHIP1 Antibody, clone 1J20 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
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human
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affinity binding assay
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
Anti-SHIP1 antibody produced in rabbit, affinity isolated antibody,
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human, mouse, rat
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ELISA
western blot
western blot
Anti-SHIP1 antibody produced in rabbit, affinity isolated antibody,
종별 반응성
human, mouse, rat
응용분야
ELISA
western blot
western blot
esiRNA
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