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  • UbcD1 regulates Hedgehog signaling by directly modulating Ci ubiquitination and processing.

UbcD1 regulates Hedgehog signaling by directly modulating Ci ubiquitination and processing.

EMBO reports (2017-09-10)
Chenyu Pan, Yue Xiong, Xiangdong Lv, Yuanxin Xia, Shuo Zhang, Hao Chen, Jialin Fan, Wenqing Wu, Feng Liu, Hailong Wu, Zhaocai Zhou, Lei Zhang, Yun Zhao
PMID28887318
ABSTRACT

The Hh pathway controls many morphogenetic processes in metazoans and plays important roles in numerous pathologies and in cancer. Hh signaling is mediated by the activity of the Gli/Ci family of transcription factors. Several studies in