- Potent Inducers of Endogenous Antimicrobial Peptides for Host Directed Therapy of Infections.
Potent Inducers of Endogenous Antimicrobial Peptides for Host Directed Therapy of Infections.
Scientific reports (2016-11-09)
H Ottosson, F Nylén, P Sarker, E Miraglia, P Bergman, G H Gudmundsson, R Raqib, B Agerberth, R Strömberg
PMID27827460
ABSTRACT
A new concept for treatment of infections is induction of our own antimicrobial peptides and the presented novel class of inducer, aroylated phenylenediamines (APDs), gives up to 20 to 30-fold induction of the human antimicrobial peptide LL-37, in vitro. In addition, oral administration of an APD in a rabbit model of Shigellosis resulted in recovery from the infection in a few days implying that APD's are promising candidates for treatment of infections.
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