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Cobalt derivatives as promising therapeutic agents.

Cobalt derivatives as promising therapeutic agents.

Current opinion in chemical biology (2012-12-29)

Marie C Heffern, Natsuho Yamamoto, Robert J Holbrook, Amanda L Eckermann, Thomas J Meade

ABSTRACT

Inorganic complexes are versatile platforms for the development of potent and selective pharmaceutical agents. Cobalt possesses a diverse array of properties that can be manipulated to yield promising drug candidates. Investigations into the mechanism of cobalt therapeutic agents can provide valuable insight into the physicochemical properties that can be harnessed for drug development. This review presents examples of bioactive cobalt complexes with special attention to their mechanisms of action. Specifically, cobalt complexes that elicit biological effects through protein inhibition, modification of drug activity, and bioreductive activation are discussed. Insights gained from these examples reveal features of cobalt that can be rationally tuned to produce therapeutics with high specificity and improved efficacy for the biomolecule or pathway of interest.

MATERIALS

Product Number

Brand

Product Description

Sigma-Aldrich

Cobalt, Carbon coated magnetic, nanopowder, <50 nm particle size (TEM), ≥99%

Sigma-Aldrich

Cobalt, powder, 2 μm particle size, 99.8% trace metals basis

Sigma-Aldrich

Cobalt, rod, diam. 5.0 mm, 99.95% trace metals basis

Sigma-Aldrich

Cobalt, pieces, 99.5% trace metals basis

Sigma-Aldrich

Cobalt, powder, <150 μm, ≥99.9% trace metals basis

Sigma-Aldrich

Cobalt, foil, thickness 0.1 mm, ≥99.99%

Cobalt, foil, not light tested, 25x25mm, thickness 0.006mm, 99.9%

Cobalt, foil, 6mm disks, thickness 0.015mm, 99.9%

Cobalt, foil, 4mm disks, thickness 0.02mm, 99.9%

Cobalt, foil, 50mm disks, thickness 0.125mm, annealed, 99.9%

Cobalt, foil, 4mm disks, thickness 0.005mm, 99.9%

Cobalt, foil, 8mm disks, thickness 0.007mm, 99.9%

Cobalt, foil, 6mm disks, thickness 0.007mm, 99.9%

Cobalt, foil, 4mm disks, thickness 0.0125mm, 99.9%

Cobalt, foil, 4mm disks, thickness 0.006mm, 99.9%

Cobalt, foil, not light tested, 25x25mm, thickness 0.007mm, 99.9%

Cobalt, foil, 8mm disks, thickness 0.008mm, 99.9%

Cobalt, foil, not light tested, 100x100mm, thickness 0.004mm, 99.9%

Cobalt, foil, 4mm disks, thickness 0.009mm, 99.9%

Cobalt, foil, not light tested, 150x150mm, thickness 0.01mm, 99.9%

Cobalt, foil, light tested, 25x25mm, thickness 0.05mm, as rolled, 99.9%

Cobalt, foil, 6mm disks, thickness 0.125mm, annealed, 99.9%

Cobalt, foil, 8mm disks, thickness 0.005mm, 99.9%

Cobalt, foil, 6mm disks, thickness 0.004mm, 99.9%

Cobalt, foil, not light tested, 25x25mm, thickness 0.008mm, 99.9%

Cobalt, foil, light tested, 25x25mm, thickness 0.01mm, 99.9%

Cobalt, foil, 6mm disks, thickness 0.05mm, as rolled, 99.9%

Cobalt, foil, not light tested, 150x150mm, thickness 0.025mm, 99.9%

Cobalt, foil, 8mm disks, thickness 0.125mm, annealed, 99.9%

Cobalt, foil, light tested, 100x100mm, thickness 0.05mm, as rolled, 99.99+%