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  • Exploring the chemistry and biology of vanadium-dependent haloperoxidases.

Exploring the chemistry and biology of vanadium-dependent haloperoxidases.

The Journal of biological chemistry (2009-04-14)
Jaclyn M Winter, Bradley S Moore
ABSTRACT

Nature has developed an exquisite array of methods to introduce halogen atoms into organic compounds. Most of these enzymes are oxidative and require either hydrogen peroxide or molecular oxygen as a cosubstrate to generate a reactive halogen atom for catalysis. Vanadium-dependent haloperoxidases contain a vanadate prosthetic group and utilize hydrogen peroxide to oxidize a halide ion into a reactive electrophilic intermediate. These metalloenzymes have a large distribution in nature, where they are present in macroalgae, fungi, and bacteria, but have been exclusively characterized in eukaryotes. In this minireview, we highlight the chemistry and biology of vanadium-dependent haloperoxidases from fungi and marine algae and the emergence of new bacterial members that extend the biological function of these poorly understood halogenating enzymes.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Vanadium, powder, −325 mesh, 99.5% trace metals basis
Sigma-Aldrich
Vanadium, foil, thickness 0.127 mm, 99.7% trace metals basis
Vanadium, wire reel, 0.5m, diameter 0.25mm, hard, 99.8%
Vanadium, wire reel, 1m, diameter 0.5mm, as drawn, 99.8%
Vanadium, wire reel, 2m, diameter 1.0mm, Stress relieved, 99.8%
Vanadium, microfoil, disks, 10mm, thinness 1.0μm, specific density 611μg/cm2, permanent mylar 3.5μm support, 99.8+%
Vanadium, wire reel, 0.5m, diameter 0.5mm, as drawn, 99.8%
Vanadium, microfoil, disks, 25mm, thinness 0.1μm, specific density 60.8μg/cm2, permanent mylar 3.5μm support, 99.8+%
Vanadium, wire reel, 0.2m, diameter 0.5mm, as drawn, 99.8%
Vanadium, wire reel, 2m, diameter 0.1mm, as drawn, 99.8%
Sigma-Aldrich
Vanadium, pieces, 1-3 mm, 99.9% trace metals basis
Sigma-Aldrich
Vanadium, powder, -100 mesh, 99.9% trace metals basis
Vanadium, wire reel, 5m, diameter 0.1mm, as drawn, 99.8%
Vanadium, wire reel, 5m, diameter 0.25mm, hard, 99.8%
Vanadium, wire reel, 1m, diameter 0.1mm, as drawn, 99.8%
Vanadium, wire reel, 5m, diameter 0.5mm, as drawn, 99.8%
Vanadium, wire reel, 1m, diameter 0.25mm, hard, 99.8%
Vanadium, wire reel, 0.5m, diameter 1.0mm, Stress relieved, 99.8%
Vanadium, wire reel, 0.2m, diameter 0.1mm, as drawn, 99.8%
Vanadium, microfoil, disks, 10mm, thinness 0.1μm, specific density 60.8μg/cm2, permanent mylar 3.5μm support, 99.8+%
Vanadium, microfoil, disks, 25mm, thinness 1.0μm, specific density 611μg/cm2, permanent mylar 3.5μm support, 99.8+%
Vanadium, wire reel, 0.5m, diameter 0.1mm, as drawn, 99.8%
Vanadium, wire reel, 0.2m, diameter 1.0mm, Stress relieved, 99.8%
Vanadium, wire reel, 0.2m, diameter 0.25mm, hard, 99.8%
Vanadium, wire reel, 2m, diameter 0.25mm, hard, 99.8%
Vanadium, wire reel, 2m, diameter 0.5mm, as drawn, 99.8%